Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-PHD |
Location | 94838..95502 | Replicon | chromosome |
Accession | NZ_CP061169 | ||
Organism | Microbacterium sp. HY60 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | HCR76_RS00505 | Protein ID | WP_166985937.1 |
Coordinates | 94838..95242 (-) | Length | 135 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | HCR76_RS00510 | Protein ID | WP_166985934.1 |
Coordinates | 95242..95502 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HCR76_RS00485 | 90109..90927 | + | 819 | WP_198248106.1 | ABC transporter ATP-binding protein | - |
HCR76_RS00490 | 90987..92024 | + | 1038 | WP_166985945.1 | iron-siderophore ABC transporter substrate-binding protein | - |
HCR76_RS00495 | 92031..94139 | + | 2109 | WP_166985942.1 | iron ABC transporter permease | - |
HCR76_RS00500 | 94192..94587 | + | 396 | WP_166985939.1 | hypothetical protein | - |
HCR76_RS00505 | 94838..95242 | - | 405 | WP_166985937.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
HCR76_RS00510 | 95242..95502 | - | 261 | WP_166985934.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
HCR76_RS00515 | 95763..99308 | + | 3546 | WP_166985932.1 | proline dehydrogenase family protein | - |
HCR76_RS00520 | 99331..99906 | - | 576 | WP_166985929.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14364.46 Da Isoelectric Point: 4.4482
>T172156 WP_166985937.1 NZ_CP061169:c95242-94838 [Microbacterium sp. HY60]
MRPAAKGLLDTSVFIALESGRPMNAEMLPDQSVICPVTIAELQAGVLSIADVDVRARRLSTLESTMDIELLAIDAEVAAH
WARLRVHLAESGRRVNVNDLWIAATAAANGVPIVTQDDDFDPLEGAHGVTVIRV
MRPAAKGLLDTSVFIALESGRPMNAEMLPDQSVICPVTIAELQAGVLSIADVDVRARRLSTLESTMDIELLAIDAEVAAH
WARLRVHLAESGRRVNVNDLWIAATAAANGVPIVTQDDDFDPLEGAHGVTVIRV
Download Length: 405 bp
>T172156 NZ_CP079629:c4099134-4098817 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9462.72 Da Isoelectric Point: 11.6548
>AT172156 WP_166985934.1 NZ_CP061169:c95502-95242 [Microbacterium sp. HY60]
MAEIAARELRNSTAEVLRRVEAGEPVTITSRGRPVAELTPVRSARRRPISRADLTRRLSRTQADSGLREDLALLAGETTD
DLGPIR
MAEIAARELRNSTAEVLRRVEAGEPVTITSRGRPVAELTPVRSARRRPISRADLTRRLSRTQADSGLREDLALLAGETTD
DLGPIR
Download Length: 261 bp
>AT172156 NZ_CP079629:c4098824-4098537 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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