Detailed information of TA system TA172156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 94838..95502
• Replicon: chromosome
• Accession: NZ_CP061169
• Organism: Microbacterium sp. HY60

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HCR76_RS00505
• Protein ID: WP_166985937.1
• Coordinates: 94838..95242 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HCR76_RS00510
• Protein ID: WP_166985934.1
• Coordinates: 95242..95502 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCR76_RS00485	90109..90927	+	819	WP_198248106.1	ABC transporter ATP-binding protein	-
HCR76_RS00490	90987..92024	+	1038	WP_166985945.1	iron-siderophore ABC transporter substrate-binding protein	-
HCR76_RS00495	92031..94139	+	2109	WP_166985942.1	iron ABC transporter permease	-
HCR76_RS00500	94192..94587	+	396	WP_166985939.1	hypothetical protein	-
HCR76_RS00505	94838..95242	-	405	WP_166985937.1	type II toxin-antitoxin system VapC family toxin	Toxin
HCR76_RS00510	95242..95502	-	261	WP_166985934.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HCR76_RS00515	95763..99308	+	3546	WP_166985932.1	proline dehydrogenase family protein	-
HCR76_RS00520	99331..99906	-	576	WP_166985929.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-46)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14364.46 Da
• Isoelectric Point: 4.4482

>T172156 WP_166985937.1 NZ_CP061169:c95242-94838 [Microbacterium sp. HY60]
MRPAAKGLLDTSVFIALESGRPMNAEMLPDQSVICPVTIAELQAGVLSIADVDVRARRLSTLESTMDIELLAIDAEVAAH
WARLRVHLAESGRRVNVNDLWIAATAAANGVPIVTQDDDFDPLEGAHGVTVIRV

Nucleotide

• Length: 405 bp

>T172156 NZ_CP079629:c4099134-4098817 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9462.72 Da
• Isoelectric Point: 11.6548

>AT172156 WP_166985934.1 NZ_CP061169:c95502-95242 [Microbacterium sp. HY60]
MAEIAARELRNSTAEVLRRVEAGEPVTITSRGRPVAELTPVRSARRRPISRADLTRRLSRTQADSGLREDLALLAGETTD
DLGPIR

Nucleotide

• Length: 261 bp

>AT172156 NZ_CP079629:c4098824-4098537 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA