172153

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1626910..1627522 Replicon chromosome
Accession NZ_CP061134
Organism Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag IB935_RS08165 Protein ID WP_002988077.1
Coordinates 1627187..1627522 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag IB935_RS08160 Protein ID WP_002988079.1
Coordinates 1626910..1627197 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IB935_RS08135 1622099..1623082 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
IB935_RS08140 1623086..1624015 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
IB935_RS08145 1624063..1624578 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
IB935_RS08150 1624613..1625041 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
IB935_RS08155 1625487..1626260 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
IB935_RS08160 1626910..1627197 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
IB935_RS08165 1627187..1627522 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IB935_RS08170 1627661..1627837 + 177 Protein_1550 tyrosine-type recombinase/integrase -
IB935_RS08175 1627968..1628360 - 393 WP_002982716.1 30S ribosomal protein S9 -
IB935_RS08180 1628381..1628827 - 447 WP_002982710.1 50S ribosomal protein L13 -
IB935_RS08185 1629045..1629251 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
IB935_RS08190 1629248..1629946 - 699 WP_021299047.1 hypothetical protein -
IB935_RS08195 1630082..1630942 - 861 WP_011529009.1 DegV family protein -
IB935_RS08200 1631039..1631557 - 519 WP_011055010.1 NYN domain-containing protein -
IB935_RS08205 1631561..1632307 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T172153 WP_002988077.1 NZ_CP061134:1627187-1627522 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T172153 NZ_CP079629:849352-849762 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT172153 WP_002988079.1 NZ_CP061134:1626910-1627197 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT172153 NZ_CP079629:849105-849371 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References