Detailed information of TA system TA172152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1620729..1621341
• Replicon: chromosome
• Accession: NZ_CP061133
• Organism: Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q1JJZ2
• Locus tag: IB936_RS08110
• Protein ID: WP_002988077.1
• Coordinates: 1621006..1621341 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: IB936_RS08105
• Protein ID: WP_002988079.1
• Coordinates: 1620729..1621016 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IB936_RS08080	1615918..1616901	-	984	WP_011529001.1	tagatose-bisphosphate aldolase	-
IB936_RS08085	1616905..1617834	-	930	WP_011529002.1	tagatose-6-phosphate kinase	-
IB936_RS08090	1617882..1618397	-	516	WP_011529003.1	galactose-6-phosphate isomerase subunit LacB	-
IB936_RS08095	1618432..1618860	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
IB936_RS08100	1619306..1620079	+	774	WP_011529005.1	DeoR/GlpR family DNA-binding transcription regulator	-
IB936_RS08105	1620729..1621016	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
IB936_RS08110	1621006..1621341	+	336	WP_002988077.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IB936_RS08115	1621480..1621656	+	177	Protein_1552	tyrosine-type recombinase/integrase	-
IB936_RS08120	1621787..1622179	-	393	WP_002982716.1	30S ribosomal protein S9	-
IB936_RS08125	1622200..1622646	-	447	WP_002982710.1	50S ribosomal protein L13	-
IB936_RS08130	1622864..1623070	-	207	WP_011529007.1	helix-turn-helix transcriptional regulator	-
IB936_RS08135	1623067..1623765	-	699	WP_021299047.1	hypothetical protein	-
IB936_RS08140	1623901..1624761	-	861	WP_011529009.1	DegV family protein	-
IB936_RS08145	1624858..1625376	-	519	WP_011055010.1	NYN domain-containing protein	-
IB936_RS08150	1625380..1626126	-	747	WP_010922667.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13117.83 Da
• Isoelectric Point: 5.2144

>T172152 WP_002988077.1 NZ_CP061133:1621006-1621341 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T172152 NZ_CP079629:347825-348193 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT172152 WP_002988079.1 NZ_CP061133:1620729-1621016 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT172152 NZ_CP079629:347607-347828 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A660A236

Antitoxin

• AlphaFold DB: A0A4U7GX94