Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1685512..1686124 Replicon chromosome
Accession NZ_CP061132
Organism Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag IB937_RS08605 Protein ID WP_002988077.1
Coordinates 1685789..1686124 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag IB937_RS08600 Protein ID WP_002988079.1
Coordinates 1685512..1685799 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IB937_RS08575 1680701..1681684 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
IB937_RS08580 1681688..1682617 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
IB937_RS08585 1682665..1683180 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
IB937_RS08590 1683215..1683643 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
IB937_RS08595 1684089..1684862 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
IB937_RS08600 1685512..1685799 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
IB937_RS08605 1685789..1686124 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IB937_RS08610 1686263..1686439 + 177 Protein_1638 tyrosine-type recombinase/integrase -
IB937_RS08615 1686570..1686962 - 393 WP_002982716.1 30S ribosomal protein S9 -
IB937_RS08620 1686983..1687429 - 447 WP_002982710.1 50S ribosomal protein L13 -
IB937_RS08625 1687647..1687853 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
IB937_RS08630 1687850..1688548 - 699 WP_021299047.1 hypothetical protein -
IB937_RS08635 1688684..1689544 - 861 WP_011529009.1 DegV family protein -
IB937_RS08640 1689641..1690159 - 519 WP_011055010.1 NYN domain-containing protein -
IB937_RS08645 1690163..1690909 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T172151 WP_002988077.1 NZ_CP061132:1685789-1686124 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T172151 NZ_CP079627:32970-33386 [Klebsiella pneumoniae subsp. pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT172151 WP_002988079.1 NZ_CP061132:1685512-1685799 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT172151 NZ_CP079627:32743-32973 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References