172150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1663411..1664023 Replicon chromosome
Accession NZ_CP061131
Organism Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag IB938_RS08430 Protein ID WP_002988077.1
Coordinates 1663688..1664023 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag IB938_RS08425 Protein ID WP_002988079.1
Coordinates 1663411..1663698 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IB938_RS08400 1658600..1659583 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
IB938_RS08405 1659587..1660516 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
IB938_RS08410 1660564..1661079 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
IB938_RS08415 1661114..1661542 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
IB938_RS08420 1661988..1662761 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
IB938_RS08425 1663411..1663698 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
IB938_RS08430 1663688..1664023 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IB938_RS08435 1664162..1664338 + 177 Protein_1603 tyrosine-type recombinase/integrase -
IB938_RS08440 1664469..1664861 - 393 WP_002982716.1 30S ribosomal protein S9 -
IB938_RS08445 1664882..1665328 - 447 WP_002982710.1 50S ribosomal protein L13 -
IB938_RS08450 1665546..1665752 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
IB938_RS08455 1665749..1666447 - 699 WP_021299047.1 hypothetical protein -
IB938_RS08460 1666583..1667443 - 861 WP_011529009.1 DegV family protein -
IB938_RS08465 1667540..1668058 - 519 WP_011055010.1 NYN domain-containing protein -
IB938_RS08470 1668062..1668808 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T172150 WP_002988077.1 NZ_CP061131:1663688-1664023 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T172150 NZ_CP079626:c14256-13906 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT172150 WP_002988079.1 NZ_CP061131:1663411-1663698 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT172150 NZ_CP079626:c13901-13599 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References