Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 8899..9491 Replicon plasmid pS304_2
Accession NZ_CP061128
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S304

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I9ZJC5
Locus tag IBY93_RS25440 Protein ID WP_000513532.1
Coordinates 8899..9147 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1I9ZJ49
Locus tag IBY93_RS25445 Protein ID WP_000681609.1
Coordinates 9144..9491 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBY93_RS25405 3911..4576 - 666 WP_000532149.1 P-loop NTPase -
IBY93_RS25410 5165..5494 + 330 WP_001542022.1 hypothetical protein -
IBY93_RS25415 5895..6410 + 516 WP_001025393.1 J domain-containing protein -
IBY93_RS25420 6514..7056 + 543 WP_001083904.1 hypothetical protein -
IBY93_RS25425 7053..7307 + 255 WP_001230709.1 hypothetical protein -
IBY93_RS25430 7304..7546 + 243 WP_000151456.1 hypothetical protein -
IBY93_RS25435 8117..8410 + 294 WP_000673428.1 hypothetical protein -
IBY93_RS25440 8899..9147 + 249 WP_000513532.1 type II toxin-antitoxin system HicA family toxin Toxin
IBY93_RS25445 9144..9491 + 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IBY93_RS25450 9579..9761 - 183 WP_001428470.1 hypothetical protein -
IBY93_RS25455 10263..10562 + 300 WP_034169410.1 type II toxin-antitoxin system HicB family antitoxin -
IBY93_RS25460 10822..11148 - 327 WP_000206697.1 hypothetical protein -
IBY93_RS25465 11150..11509 - 360 WP_196315155.1 hypothetical protein -
IBY93_RS25470 11610..12317 - 708 WP_000108794.1 hypothetical protein -
IBY93_RS25475 12319..13071 - 753 WP_000797966.1 conjugal transfer protein TraL -
IBY93_RS25480 13089..13490 - 402 WP_021575837.1 hypothetical protein -
IBY93_RS25485 13858..14199 + 342 WP_000730722.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..60870 60870


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 10656.47 Da        Isoelectric Point: 12.7138

>T172149 WP_000513532.1 NZ_CP061128:8899-9147 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Download         Length: 249 bp

>T172149 NZ_CP079625:58923-59405 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 14886.21 Da        Isoelectric Point: 12.8607

>AT172149 WP_000681609.1 NZ_CP061128:9144-9491 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 348 bp

>AT172149 NZ_CP079625:58669-58935 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9ZJC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1I9ZJ49

References