Detailed information of TA system TA172148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/MqsA(antitoxin)
• Location: 7053..7546
• Replicon: plasmid pS304_2
• Accession: NZ_CP061128
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S304

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: U9Y9W8
• Locus tag: IBY93_RS25425
• Protein ID: WP_001230709.1
• Coordinates: 7053..7307 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: U9Y4R8
• Locus tag: IBY93_RS25430
• Protein ID: WP_000151456.1
• Coordinates: 7304..7546 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBY93_RS25390	2628..2789	+	162	WP_001366886.1	type I toxin-antitoxin system Hok family toxin	-
IBY93_RS25395	2939..3535	+	597	WP_000125165.1	hypothetical protein	-
IBY93_RS25400	3553..3837	-	285	WP_001162371.1	hypothetical protein	-
IBY93_RS25405	3911..4576	-	666	WP_000532149.1	P-loop NTPase	-
IBY93_RS25410	5165..5494	+	330	WP_001542022.1	hypothetical protein	-
IBY93_RS25415	5895..6410	+	516	WP_001025393.1	J domain-containing protein	-
IBY93_RS25420	6514..7056	+	543	WP_001083904.1	hypothetical protein	-
IBY93_RS25425	7053..7307	+	255	WP_001230709.1	hypothetical protein	Toxin
IBY93_RS25430	7304..7546	+	243	WP_000151456.1	hypothetical protein	Antitoxin
IBY93_RS25435	8117..8410	+	294	WP_000673428.1	hypothetical protein	-
IBY93_RS25440	8899..9147	+	249	WP_000513532.1	type II toxin-antitoxin system HicA family toxin	-
IBY93_RS25445	9144..9491	+	348	WP_000681609.1	type II toxin-antitoxin system HicB family antitoxin	-
IBY93_RS25450	9579..9761	-	183	WP_001428470.1	hypothetical protein	-
IBY93_RS25455	10263..10562	+	300	WP_034169410.1	type II toxin-antitoxin system HicB family antitoxin	-
IBY93_RS25460	10822..11148	-	327	WP_000206697.1	hypothetical protein	-
IBY93_RS25465	11150..11509	-	360	WP_196315155.1	hypothetical protein	-
IBY93_RS25470	11610..12317	-	708	WP_000108794.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..60870	60870

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (16-47)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10912.81 Da
• Isoelectric Point: 12.7242

>T172148 WP_001230709.1 NZ_CP061128:7053-7307 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKK

Nucleotide

• Length: 255 bp

>T172148 NZ_CP079624:c5424775-5424392 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 10400.12 Da
• Isoelectric Point: 12.7030

>AT172148 WP_000151456.1 NZ_CP061128:7304-7546 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Nucleotide

• Length: 243 bp

>AT172148 NZ_CP079624:c5425017-5424775 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: A0A3G9H8F0

Antitoxin

• AlphaFold DB: A0A3G9GNF5