Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4447748..4448792 Replicon chromosome
Accession NZ_CP061108
Organism Escherichia coli strain 1EC187

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag IBZ91_RS21290 Protein ID WP_000019186.1
Coordinates 4447748..4448296 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag IBZ91_RS21295 Protein ID WP_000287252.1
Coordinates 4448319..4448792 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBZ91_RS21255 4442960..4443511 - 552 WP_000515860.1 hypothetical protein -
IBZ91_RS21260 4443555..4443755 - 201 WP_000649477.1 helix-turn-helix domain-containing protein -
IBZ91_RS21265 4443846..4444520 + 675 WP_000859462.1 LexA family transcriptional repressor -
IBZ91_RS21270 4445187..4445549 + 363 WP_000135682.1 hypothetical protein -
IBZ91_RS21275 4445615..4446439 + 825 WP_001753751.1 DUF2303 family protein -
IBZ91_RS21280 4446656..4447408 + 753 WP_001701368.1 hypothetical protein -
IBZ91_RS21285 4447445..4447714 + 270 WP_001093912.1 pyocin activator PrtN family protein -
IBZ91_RS21290 4447748..4448296 - 549 WP_000019186.1 hypothetical protein Toxin
IBZ91_RS21295 4448319..4448792 - 474 WP_000287252.1 SocA family protein Antitoxin
IBZ91_RS21300 4449079..4449201 - 123 WP_001300034.1 hypothetical protein -
IBZ91_RS21305 4449564..4450580 - 1017 WP_000912595.1 DUF2713 family protein -
IBZ91_RS21310 4450898..4451413 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
IBZ91_RS21315 4451455..4451664 - 210 WP_001030593.1 CsbD family protein -
IBZ91_RS21320 4451780..4453105 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
IBZ91_RS21325 4453178..4453786 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4425951..4453786 27835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T172138 WP_000019186.1 NZ_CP061108:c4448296-4447748 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T172138 NZ_CP079618:c14256-13906 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT172138 WP_000287252.1 NZ_CP061108:c4448792-4448319 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT172138 NZ_CP079618:c13901-13599 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References