Detailed information of TA system TA172098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2376263..2377851
• Replicon: chromosome
• Accession: NZ_CP061101
• Organism: Escherichia coli strain 1EC213

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: U9XU38
• Locus tag: IB009_RS11600
• Protein ID: WP_001125455.1
• Coordinates: 2376529..2377851 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IB009_RS11595
• Protein ID: WP_001296726.1
• Coordinates: 2376263..2376529 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IB009_RS11595	2376263..2376529	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IB009_RS11600	2376529..2377851	+	1323	WP_001125455.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
IB009_RS11605	2378163..2378371	+	209	Protein_2268	helix-turn-helix transcriptional regulator	-
IB009_RS11610	2378897..2379594	+	698	Protein_2269	IS1 family transposase	-
IB009_RS11615	2379880..2382159	+	2280	WP_001460947.1	acid resistance putative oxidoreductase YdeP	-
IB009_RS11620	2382407..2382604	+	198	WP_000543389.1	two-component system connector SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2379217..2379594	377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49321.93 Da
• Isoelectric Point: 8.8753

>T172098 WP_001125455.1 NZ_CP061101:2376529-2377851 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T172098 NZ_CP079223:31978-32262 [Zymomonas mobilis]
ATGGCTTGGAAAATTGAATTCGATCCAGCCGCGCAAAAAGAGTTGAAAAAATTAGGAACACAGCCAGCTAAGCGGATCTT
AAGATTTTTATCTGAACGATTGGCCTTGGCTGATGACCCAAGGTCATTTGGGGCAGCTTTAAAGGGAACAACACTAGGTA
ATTTATGGAAGTATCGAATTGGTGATTACCGCATCATTGCAGATATTGAAGATAATGTGATGCGGATTTTGGTTGTCCGA
ATTGGTAATAGAAGAGAAATTTATAAAAAAGCCGTCAGGCATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT172098 WP_001296726.1 NZ_CP061101:2376263-2376529 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT172098 NZ_CP079223:31770-31994 [Zymomonas mobilis]
ATGTTAGCGATCAGACTACCAGAAGAAATAGAAGACCGTTTAAGTGCATTAGCCAATGCAACAGGTAGAACTAAGACTTT
CTATGCCAGAGAAGCCATACTTCATCATTTGGAAGAGCTTGAGGATATTTATCTAGCAGAAGCGCGCGCAGTTAAAATCC
GTTCCGGCCAGACTAAGACTGTCCCATTAGAAAATATTATGGCCGAATATGGCTTGGAAAATTGA

Structures

Toxin

• AlphaFold DB: U9XU38