Detailed information of TA system TA172082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-PrlF
• Location: 21556..22111
• Replicon: plasmid p1318-6
• Accession: NZ_CP061097
• Organism: Roseomonas marmotae strain 1318

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: IAI58_RS22385
• Protein ID: WP_207451561.1
• Coordinates: 21761..22111 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: IAI58_RS22380
• Protein ID: WP_207451571.1
• Coordinates: 21556..21774 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAI58_RS22365 (IAI58_22350)	19452..20285	-	834	WP_207451271.1	HNH endonuclease signature motif containing protein	-
IAI58_RS22370 (IAI58_22355)	20381..20485	+	105	WP_207451269.1	excalibur calcium-binding domain-containing protein	-
IAI58_RS22375 (IAI58_22360)	20545..21459	+	915	WP_207451563.1	3'-5' exonuclease	-
IAI58_RS22380 (IAI58_22365)	21556..21774	+	219	WP_207451571.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
IAI58_RS22385 (IAI58_22370)	21761..22111	+	351	WP_207451561.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
IAI58_RS22390 (IAI58_22375)	22794..22964	+	171	WP_208776343.1	hypothetical protein	-
IAI58_RS22395 (IAI58_22380)	23147..25927	+	2781	WP_208776344.1	virulence-associated E family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59993	59993

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-110)

Antitoxin

• PrlF antitoxin (4-53)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12406.32 Da
• Isoelectric Point: 5.0807

>T172082 WP_207451561.1 NZ_CP061097:21761-22111 [Roseomonas marmotae]
MPGFEVWDLVKVPFPYTNRPVQQRRPALVIAAPEASGTPALLWVLMVTSAENRGWPGDVMVSDLTEAGLPAPSVVRPAKI
ATIEAGDAERIGRLPEPDQRQVAQALRASLGGVLAQ

Nucleotide

• Length: 351 bp

>T172082 NZ_CP079193:967869-968135 [Streptococcus suis]
ATGAAGACCAGTTATAAACTCGTACCAACCGGTCGTTTTATCAAACAGTTGAAAAAGCTGGACAAATTTACTCAAAAGCA
GATTACCAACTACCTGTCTAGTCATGTGACCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAATTGATTGTAACGGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8032.09 Da
• Isoelectric Point: 6.2833

>AT172082 WP_207451571.1 NZ_CP061097:21556-21774 [Roseomonas marmotae]
MITSRLTSKAQTTIPQPVRAALRLREGDEIAYTIEQGRVVLTRVQPERAADDPFRTFAEWESPADAKAYAGL

Nucleotide

• Length: 219 bp

>AT172082 NZ_CP079193:967634-967885 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTGAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCACTTGAAGATGAGTACGATGCGCGTGTGGCTGACATTGCACTTGCAG
AATACGAGGCTGACTTGGCGAATGGCATTGAGCCGATAAGCTGGGAGGAAATGTTGGAAGATTTGGGGCTGACGGATGAA
GACCAGTTATAA