Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 227680..228268 Replicon chromosome
Accession NZ_CP061088
Organism Brucella sp. 6810

Toxin (Protein)


Gene name PumA Uniprot ID A0A7L7ML11
Locus tag IB024_RS01235 Protein ID WP_008505629.1
Coordinates 227978..228268 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7L7ML36
Locus tag IB024_RS01230 Protein ID WP_008505633.1
Coordinates 227680..227976 (-) Length 99 a.a.

Genomic Context

IB024_RS01205IB024_RS01210IB024_RS01215IB024_RS01220IB024_RS01245IB024_RS01250IB024_RS01255IB024_RS01260IB024_RS01265IB024_RS01270IB024_RS01275IB024_RS01280IB024_RS01225IB024_RS01230IB024_RS01235IB024_RS01240
Location: 222869..223997 (1129 bp)
Type: Others
Protein ID: WP_011950188.1
Location: 224131..225630 (1500 bp)
Type: Others
Protein ID: WP_187959937.1
Location: 225632..226366 (735 bp)
Type: Others
Protein ID: WP_151653755.1
Location: 226516..226698 (183 bp)
Type: Others
Protein ID: WP_187960040.1
Location: 228767..229333 (567 bp)
Type: Others
Protein ID: WP_187960043.1
Location: 229330..229554 (225 bp)
Type: Others
Protein ID: WP_187960044.1
Location: 229556..230242 (687 bp)
Type: Others
Protein ID: WP_210310604.1
Location: 230242..230481 (240 bp)
Type: Others
Protein ID: WP_187960045.1
Location: 230481..230849 (369 bp)
Type: Others
Protein ID: WP_187960505.1
Location: 231114..232199 (1086 bp)
Type: Others
Protein ID: WP_187960046.1
Location: 232174..232506 (333 bp)
Type: Others
Protein ID: WP_187960047.1
Location: 232499..232981 (483 bp)
Type: Others
Protein ID: WP_187960048.1
Location: 226724..227620 (897 bp)
Type: Others
Protein ID: WP_187960041.1
Location: 227680..227976 (297 bp)
Type: Antitoxin
Protein ID: WP_008505633.1
Location: 227978..228268 (291 bp)
Type: Toxin
Protein ID: WP_008505629.1
Location: 228389..228655 (267 bp)
Type: Others
Protein ID: WP_187960042.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IB024_RS01205222869..223997+1129WP_011950188.1peptide chain release factor 2-
IB024_RS01210224131..225630+1500WP_187959937.1IS21 family transposase-
IB024_RS01215225632..226366+735WP_151653755.1IS21-like element helper ATPase IstB-
IB024_RS01220226516..226698+183WP_187960040.1hypothetical protein-
IB024_RS01225226724..227620-897WP_187960041.1hypothetical protein-
IB024_RS01230227680..227976-297WP_008505633.1putative addiction module antidote proteinAntitoxin
IB024_RS01235227978..228268-291WP_008505629.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IB024_RS01240228389..228655-267WP_187960042.1Arc family DNA-binding protein-
IB024_RS01245228767..229333+567WP_187960043.1phage P22, antirepressor protein-
IB024_RS01250229330..229554+225WP_187960044.1Arc family DNA-binding protein-
IB024_RS01255229556..230242+687WP_210310604.1Rha family transcriptional regulator-
IB024_RS01260230242..230481+240WP_187960045.1hypothetical protein-
IB024_RS01265230481..230849+369WP_187960505.1hypothetical protein-
IB024_RS01270231114..232199+1086WP_187960046.1hypothetical protein-
IB024_RS01275232174..232506+333WP_187960047.1STAS-like domain-containing protein-
IB024_RS01280232499..232981+483WP_187960048.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--218769..24753728768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10724.46 Da        Isoelectric Point: 10.2779

>T172077 WP_008505629.1 NZ_CP061088:c228268-227978 [Brucella sp. 6810]
MIEVRQTTAFTKWLNELRDTNARLRIATRIRRMELGNPGDVKAVGEGVSEMRITYGPGYRVYFVTMGSTIVVLLCGGDKS
SQSRDIAVAKQMAKEI

Download         Length: 291 bp

>T172077 NZ_CP079186:c4857371-4857087 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10440.88 Da        Isoelectric Point: 5.1057

>AT172077 WP_008505633.1 NZ_CP061088:c227976-227680 [Brucella sp. 6810]
MALETTRFDILDHLKTPEERLAYLEAAFEDGDPSLIAHALGDVARSVGMTAVAKEAGITREALYRSLSENGDPKLSTLLG
VTKALGIHLTVGPDKHAA

Download         Length: 297 bp

>AT172077 NZ_CP079186:c4857603-4857361 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7L7ML11

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7L7ML36

References