Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 136501..137171 Replicon chromosome
Accession NZ_CP061088
Organism Brucella sp. 6810

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IB024_RS00780 Protein ID WP_076770566.1
Coordinates 136767..137171 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D1CXH4
Locus tag IB024_RS00775 Protein ID WP_008504606.1
Coordinates 136501..136770 (+) Length 90 a.a.

Genomic Context

IB024_RS00755IB024_RS00770IB024_RS00775IB024_RS00780IB024_RS00785IB024_RS00790IB024_RS00760IB024_RS00765IB024_RS00795IB024_RS00800IB024_RS00805
Location: 133523..133720 (198 bp)
Type: Others
Protein ID: WP_002963959.1
Location: 135752..136369 (618 bp)
Type: Others
Protein ID: WP_076779584.1
Location: 136501..136770 (270 bp)
Type: Antitoxin
Protein ID: WP_008504606.1
Location: 136767..137171 (405 bp)
Type: Toxin
Protein ID: WP_076770566.1
Location: 137470..138351 (882 bp)
Type: Others
Protein ID: WP_002969416.1
Location: 138338..139165 (828 bp)
Type: Others
Protein ID: WP_187960445.1
Location: 133765..134178 (414 bp)
Type: Others
Protein ID: WP_008935646.1
Location: 134446..135417 (972 bp)
Type: Others
Protein ID: WP_187960444.1
Location: 139219..140484 (1266 bp)
Type: Others
Protein ID: WP_187960004.1
Location: 140753..141085 (333 bp)
Type: Others
Protein ID: WP_009364410.1
Location: 141267..141503 (237 bp)
Type: Others
Protein ID: WP_008505519.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IB024_RS00755133523..133720+198WP_002963959.1DUF3008 family protein-
IB024_RS00760133765..134178-414WP_008935646.1hypothetical protein-
IB024_RS00765134446..135417-972WP_187960444.1extensin family protein-
IB024_RS00770135752..136369+618WP_076779584.130S ribosomal protein S4-
IB024_RS00775136501..136770+270WP_008504606.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
IB024_RS00780136767..137171+405WP_076770566.1type II toxin-antitoxin system VapC family toxinToxin
IB024_RS00785137470..138351+882WP_002969416.1tRNA 2-thiocytidine(32) synthetase TtcA-
IB024_RS00790138338..139165+828WP_187960445.1inositol monophosphatase family protein-
IB024_RS00795139219..140484-1266WP_187960004.1multidrug effflux MFS transporter-
IB024_RS00800140753..141085-333WP_009364410.1Grx4 family monothiol glutaredoxin-
IB024_RS00805141267..141503-237WP_008505519.1BolA family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-118)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14305.62 Da        Isoelectric Point: 5.6357

>T172076 WP_076770566.1 NZ_CP061088:136767-137171 [Brucella sp. 6810]
MSKLYMLDTNIVSDLARNPHGPVAKHIARVGADAICVSIITACELRYGCAKKGSPRLLAQIEAILDSIEILPLDVPADTE
YGGIRAELEADGKPIGPNDFLIAAHACALGAVLVTANVGEFTRIRKLAVENWLN

Download         Length: 405 bp

>T172076 NZ_CP079186:c4725380-4724847 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGATTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10046.62 Da        Isoelectric Point: 7.2059

>AT172076 WP_008504606.1 NZ_CP061088:136501-136770 [Brucella sp. 6810]
MAHARRIEPTPAREAKLFRNNKSQAVRIPADFEFPGNRVLIHREGDKLIIEPVRRKNLLEVLAGLKPLGPEDAFPDIDDT
ALPLKDVDL

Download         Length: 270 bp

>AT172076 NZ_CP079186:c4725657-4725391 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7L7MKG1

References