Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3070892..3071509 Replicon chromosome
Accession NZ_CP061083
Organism Pantoea sp. MT58

Toxin (Protein)


Gene name Hha Uniprot ID E0LTU7
Locus tag IAI47_RS14555 Protein ID WP_003850458.1
Coordinates 3071294..3071509 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E0LTU8
Locus tag IAI47_RS14550 Protein ID WP_003850455.1
Coordinates 3070892..3071269 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI47_RS14520 3067202..3067462 + 261 WP_008924911.1 type B 50S ribosomal protein L31 -
IAI47_RS14525 3067466..3067606 + 141 WP_003850445.1 type B 50S ribosomal protein L36 -
IAI47_RS14530 3067652..3068530 - 879 WP_187961148.1 metal ABC transporter substrate-binding protein -
IAI47_RS14535 3068546..3069385 - 840 WP_003850449.1 metal ABC transporter permease -
IAI47_RS14540 3069382..3070050 - 669 WP_008924910.1 ABC transporter ATP-binding protein -
IAI47_RS14545 3070391..3070744 + 354 WP_008924909.1 hypothetical protein -
IAI47_RS14550 3070892..3071269 + 378 WP_003850455.1 Hha toxicity modulator TomB Antitoxin
IAI47_RS14555 3071294..3071509 + 216 WP_003850458.1 hemolysin expression modulator Hha Toxin
IAI47_RS14565 3071929..3072246 + 318 WP_003850460.1 MGMT family protein -
IAI47_RS14570 3072277..3072834 - 558 WP_008924908.1 YbaY family lipoprotein -
IAI47_RS14575 3073025..3073888 + 864 WP_008924907.1 acyl-CoA thioesterase II -
IAI47_RS14580 3073938..3075224 - 1287 WP_003850465.1 ammonium transporter AmtB -
IAI47_RS14585 3075259..3075597 - 339 WP_003850469.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8510.90 Da        Isoelectric Point: 9.4825

>T172071 WP_003850458.1 NZ_CP061083:3071294-3071509 [Pantoea sp. MT58]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 216 bp

>T172071 NZ_CP079186:872892-873302 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14636.25 Da        Isoelectric Point: 4.3976

>AT172071 WP_003850455.1 NZ_CP061083:3070892-3071269 [Pantoea sp. MT58]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT172071 NZ_CP079186:872645-872911 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5AGC3

Antitoxin

Source ID Structure
AlphaFold DB A0A1I5AG55

References