Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2103191..2104817 Replicon chromosome
Accession NZ_CP061083
Organism Pantoea sp. MT58

Toxin (Protein)


Gene name hipA Uniprot ID E0LV81
Locus tag IAI47_RS09935 Protein ID WP_008925194.1
Coordinates 2103492..2104817 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID E0LV82
Locus tag IAI47_RS09930 Protein ID WP_008925195.1
Coordinates 2103191..2103487 (+) Length 99 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI47_RS09915 2098666..2100048 + 1383 WP_008925198.1 M24 family metallopeptidase -
IAI47_RS09920 2100163..2102208 + 2046 WP_008925197.1 FUSC family protein -
IAI47_RS09925 2102548..2102883 - 336 WP_008925196.1 gamma-glutamylcyclotransferase -
IAI47_RS09930 2103191..2103487 + 297 WP_008925195.1 helix-turn-helix domain-containing protein Antitoxin
IAI47_RS09935 2103492..2104817 + 1326 WP_008925194.1 type II toxin-antitoxin system HipA family toxin Toxin
IAI47_RS09940 2105207..2106226 - 1020 WP_008925193.1 alpha/beta hydrolase -
IAI47_RS09945 2106717..2107139 + 423 WP_008925192.1 hydroxyisourate hydrolase -
IAI47_RS09950 2107156..2107577 - 422 Protein_1936 hypothetical protein -
IAI47_RS09955 2107571..2107855 + 285 Protein_1937 SDR family oxidoreductase -
IAI47_RS09960 2108100..2109200 + 1101 WP_008925189.1 NADH:flavin oxidoreductase/NADH oxidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(155-406)

Antitoxin

(21-69)


Sequences


Toxin        


Download         Length: 442 a.a.        Molecular weight: 50159.05 Da        Isoelectric Point: 6.0674

>T172070 WP_008925194.1 NZ_CP061083:2103492-2104817 [Pantoea sp. MT58]
MSRRQQRLVIWMNGIQVGFWNKSKGEDTLQYLPEWSADAQGRPLSLSLPFTPGDQIWRGNVVRDYFDNLLPDSEGIRRRL
AMRYQAESLDPFDLLTELGKDCVGAIQLLKEGDEPTDLYCVKYRPLSESEIAMTLRNTTAASLPGRQSDTGDLRLSIAGA
QEKTALLWHDDRWCRPEGNTPTTHIFKLPLGLVGNMKADMSTSVENEWLCSLLLEQFGIPVARTEIAQFEDQKVLVVERF
DRKWSGDQRWIIRLPQEDMCQAAGMSPLRKYQADGGPGISEIMEILSHSDHAEQDRLHFFKAQIIFWVLAATDGHAKNFS
IAIGPQGHYCLTPLYDVLSAWSVIGNGNNQIAWQKCKLAMAARGSSNYYKLYRIQRRHWINHGEQTGLSKKQVEMMMDEI
ISDAPDVIERVRAQLPDQFPSELAERVFDGITQQCRRLAGN

Download         Length: 1326 bp

>T172070 NZ_CP079186:335828-336196 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10966.66 Da        Isoelectric Point: 10.8315

>AT172070 WP_008925195.1 NZ_CP061083:2103191-2103487 [Pantoea sp. MT58]
MKNVYPIKTLSQLRPLLIGFRKANGLTQKDLSERLGVTQQTYARLEANPARASIERLFKIFTLLGVEMTLSSGISSSAGK
QTEEKGTLENSPARREKW

Download         Length: 297 bp

>AT172070 NZ_CP079186:335610-335831 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB E0LV81


Antitoxin

Source ID Structure
AlphaFold DB E0LV82

References