Detailed information of TA system TA172069

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2096498..2098056
• Replicon: chromosome
• Accession: NZ_CP061083
• Organism: Pantoea sp. MT58

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: E0LV87
• Locus tag: IAI47_RS09905
• Protein ID: WP_008925199.1
• Coordinates: 2096746..2098056 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IAI47_RS09900
• Protein ID: WP_008925200.1
• Coordinates: 2096498..2096746 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAI47_RS09880	2091753..2093978	+	2226	WP_008925203.1	iron ABC transporter permease	-
IAI47_RS09885	2093975..2095036	+	1062	WP_003853623.1	ABC transporter ATP-binding protein	-
IAI47_RS09890	2095060..2095854	+	795	WP_008925202.1	inositol monophosphatase	-
IAI47_RS09895	2095884..2096321	-	438	WP_008925201.1	GNAT family N-acetyltransferase	-
IAI47_RS09900	2096498..2096746	+	249	WP_008925200.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IAI47_RS09905	2096746..2098056	+	1311	WP_008925199.1	type II toxin-antitoxin system HipA family toxin	Toxin
IAI47_RS09910	2098158..2098364	+	207	WP_003853616.1	type II toxin-antitoxin system MqsA family antitoxin	-
IAI47_RS09915	2098666..2100048	+	1383	WP_008925198.1	M24 family metallopeptidase	-
IAI47_RS09920	2100163..2102208	+	2046	WP_008925197.1	FUSC family protein	-
IAI47_RS09925	2102548..2102883	-	336	WP_008925196.1	gamma-glutamylcyclotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-64)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49054.37 Da
• Isoelectric Point: 6.8328

>T172069 WP_008925199.1 NZ_CP061083:2096746-2098056 [Pantoea sp. MT58]
MQRLIAWMNGERVGVLTRQRNGTHAFQYDTGWLSNPLSRPLSLSMPLQVKAITSHAVINFFDNLLPDSPLIRERIAARYQ
TQSCEPFDLLQEVGRDTVGAIMLLPPDRPLPAVQARYEVLDEARLESVLSARYDIPLGMLHEEPDFRLSVAGAQEKTALL
LSQEGWSIPAGGTSASHIIKLPVGEIKQPTATLDMRESVENEYLCLTLARALGINVPQATIIRAGKMRALAVERFDRRWS
RDKTRLIRLPQEDFCQALGLTSSTQYESDGGPGIAEIMQILMGSRHAIEDRYRFMMFQVFQWLIGATDGHARNFSLFIER
GGSYRLTPFYDVISAYPVQSGSGMNTQTLTLAMGLGATQEKRTEIDKIYPRHFIATAKQVSFDRDSLQQIFDFFIKALPQ
AIVLVRDALPPDFPQHIADAIFSHALIMLERLRHGE

Nucleotide

• Length: 1311 bp

>T172069 NZ_CP079181:53367-53672 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9264.52 Da
• Isoelectric Point: 6.2126

>AT172069 WP_008925200.1 NZ_CP061083:2096498-2096746 [Pantoea sp. MT58]
MIYSPIQLANQLKFIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQALEVSLAVQEKEGVTATHLHDED
EW

Nucleotide

• Length: 249 bp

>AT172069 NZ_CP079181:53147-53365 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: E0LV87