Detailed information of TA system TA172066

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4393793..4394462
• Replicon: chromosome
• Accession: NZ_CP061082
• Organism: Serratia liquefaciens strain MT49

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IAI46_RS20755
• Protein ID: WP_187961870.1
• Coordinates: 4393793..4394215 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7W4F6J9
• Locus tag: IAI46_RS20760
• Protein ID: WP_020828476.1
• Coordinates: 4394196..4394462 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAI46_RS20735	4389679..4390197	+	519	WP_020828471.1	flavodoxin FldB	-
IAI46_RS20740	4390234..4391598	-	1365	WP_187961868.1	cell envelope integrity protein CreD	-
IAI46_RS20745	4391683..4393101	-	1419	WP_187961869.1	two-component system sensor histidine kinase CreC	-
IAI46_RS20750	4393098..4393793	-	696	WP_046372714.1	two-component system response regulator CreB	-
IAI46_RS20755	4393793..4394215	-	423	WP_187961870.1	protein YgfX	Toxin
IAI46_RS20760	4394196..4394462	-	267	WP_020828476.1	FAD assembly factor SdhE	Antitoxin
IAI46_RS20765	4394785..4395771	+	987	WP_187961871.1	tRNA-modifying protein YgfZ	-
IAI46_RS20770	4395829..4396326	-	498	WP_020828478.1	DUF2165 domain-containing protein	-
IAI46_RS20775	4396491..4397165	-	675	WP_020828479.1	hemolysin III family protein	-
IAI46_RS20780	4397349..4397957	+	609	WP_048760837.1	HD domain-containing protein	-
IAI46_RS20785	4397998..4399323	-	1326	WP_046372712.1	MHS family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16588.53 Da
• Isoelectric Point: 10.6958

>T172066 WP_187961870.1 NZ_CP061082:c4394215-4393793 [Serratia liquefaciens]
VAQWRCDVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLEHQRVGWQGQ
EWQLSKQPWMLRFGILLTLQPMQGKKRRRLWLASDSMAKAEWRHLRQQLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T172066 NZ_CP079179:c5340694-5340311 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.99 Da
• Isoelectric Point: 5.0990

>AT172066 WP_020828476.1 NZ_CP061082:c4394462-4394196 [Serratia liquefaciens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDRLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT172066 NZ_CP079179:c5340936-5340694 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F6J9