Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4009674..4010326 Replicon chromosome
Accession NZ_CP061082
Organism Serratia liquefaciens strain MT49

Toxin (Protein)


Gene name vapC Uniprot ID A0A379YFT9
Locus tag IAI46_RS19000 Protein ID WP_020828096.1
Coordinates 4009674..4010060 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A379YGI8
Locus tag IAI46_RS19005 Protein ID WP_020828097.1
Coordinates 4010063..4010326 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI46_RS18985 4006139..4007569 + 1431 WP_187961766.1 MFS transporter -
IAI46_RS18990 4007569..4008951 + 1383 WP_046372938.1 two-component system sensor histidine kinase BaeS -
IAI46_RS18995 4008951..4009667 + 717 WP_020828095.1 two-component system response regulator BaeR -
IAI46_RS19000 4009674..4010060 - 387 WP_020828096.1 type II toxin-antitoxin system VapC family toxin Toxin
IAI46_RS19005 4010063..4010326 - 264 WP_020828097.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IAI46_RS19010 4010678..4011016 + 339 WP_020828098.1 YegP family protein -
IAI46_RS19015 4011317..4012669 + 1353 WP_041414820.1 tRNA 5-hydroxyuridine modification protein YegQ -
IAI46_RS19020 4013143..4014060 + 918 WP_129983486.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14093.28 Da        Isoelectric Point: 7.8799

>T172065 WP_020828096.1 NZ_CP061082:c4010060-4009674 [Serratia liquefaciens]
MYMFDTNTVSQLFRRHPRLLSLMEKIPPSAVCISSITQAELLYGVAKRQNLALKATVAAFLDSVTVYAWDSEAAHCYGTL
RAEMTQKGRVMGALDQLIAAHAQSRGATIVTNDRAFAMVPGLTVEDWT

Download         Length: 387 bp

>T172065 NZ_CP079179:c4855308-4855024 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10091.38 Da        Isoelectric Point: 5.8701

>AT172065 WP_020828097.1 NZ_CP061082:c4010326-4010063 [Serratia liquefaciens]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIEKTQVPHDFLAADERQQGSATR
DPFAGEE

Download         Length: 264 bp

>AT172065 NZ_CP079179:c4855540-4855298 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379YFT9

Antitoxin

Source ID Structure
AlphaFold DB A0A379YGI8

References