Detailed information of TA system TA172064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3310797..3311422
• Replicon: chromosome
• Accession: NZ_CP061082
• Organism: Serratia liquefaciens strain MT49

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A515CU05
• Locus tag: IAI46_RS15750
• Protein ID: WP_048760244.1
• Coordinates: 3310797..3310979 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IAI46_RS15755
• Protein ID: WP_048760245.1
• Coordinates: 3311009..3311422 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAI46_RS15745	3306659..3310630	+	3972	WP_046373266.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
IAI46_RS15750	3310797..3310979	+	183	WP_048760244.1	type II toxin-antitoxin system HicA family toxin	Toxin
IAI46_RS15755	3311009..3311422	+	414	WP_048760245.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IAI46_RS15760	3311454..3312206	-	753	WP_046373263.1	L-cystine ABC transporter ATP-binding protein YecC	-
IAI46_RS15765	3312210..3312872	-	663	WP_020827487.1	cystine ABC transporter permease	-
IAI46_RS15770	3312872..3313672	-	801	WP_046373262.1	cystine ABC transporter substrate-binding protein	-
IAI46_RS15775	3313787..3314779	-	993	WP_187961585.1	D-cysteine desulfhydrase	-
IAI46_RS15780	3314907..3315416	-	510	WP_041414695.1	flagella biosynthesis regulatory protein FliZ	-
IAI46_RS15785	3315475..3316197	-	723	WP_020827491.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6768.95 Da
• Isoelectric Point: 10.7801

>T172064 WP_048760244.1 NZ_CP061082:3310797-3310979 [Serratia liquefaciens]
VKSSELIGLLEQEGWVLTRIKGSHHQFKHPNSRLVITVPHPRKDLKAGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T172064 NZ_CP079179:c4723317-4722784 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGATTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15093.75 Da
• Isoelectric Point: 4.8403

>AT172064 WP_048760245.1 NZ_CP061082:3311009-3311422 [Serratia liquefaciens]
MFYPAYVHSEPDGSASGFFPDVPGCYFAGDTLDRAFEDARSALDAHFEFLSEDNQPIPGPQAVTFHLAQNNDSLNGGQWL
LVNINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Nucleotide

• Length: 414 bp

>AT172064 NZ_CP079179:c4723594-4723328 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A515CU05