Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yafW/CbtA-CbeA
Location 1227338..1228092 Replicon chromosome
Accession NZ_CP061082
Organism Serratia liquefaciens strain MT49

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag IAI46_RS05695 Protein ID WP_187962422.1
Coordinates 1227724..1228092 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID -
Locus tag IAI46_RS05690 Protein ID WP_187962421.1
Coordinates 1227338..1227649 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI46_RS05665 1223369..1224253 + 885 WP_187962418.1 hypothetical protein -
IAI46_RS05670 1224994..1225341 + 348 WP_187962419.1 hypothetical protein -
IAI46_RS05675 1225652..1226128 + 477 WP_187962420.1 hypothetical protein -
IAI46_RS05680 1226365..1226814 + 450 Protein_1090 antirestriction protein -
IAI46_RS05685 1226847..1227326 + 480 WP_187962939.1 DNA repair protein RadC -
IAI46_RS05690 1227338..1227649 + 312 WP_187962421.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IAI46_RS05695 1227724..1228092 + 369 WP_187962422.1 TA system toxin CbtA family protein Toxin
IAI46_RS05700 1228224..1229057 + 834 WP_187962423.1 DUF4942 domain-containing protein -
IAI46_RS05705 1229800..1229958 + 159 WP_020825576.1 hypothetical protein -
IAI46_RS05710 1230208..1230387 + 180 WP_187962424.1 hypothetical protein -
IAI46_RS05715 1231070..1231290 + 221 Protein_1097 DNA polymerase III subunit theta -
IAI46_RS05720 1231612..1232031 - 420 WP_128864451.1 DoxX family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1164724..1236671 71947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(7-102)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13705.68 Da        Isoelectric Point: 6.2117

>T172055 WP_187962422.1 NZ_CP061082:1227724-1228092 [Serratia liquefaciens]
MQTLPVTPKRVVYACPSPVVVWQSMLTYLLGQHYGLALNDTEFSDDTVIHEHIDAGISLADALNFTVEQFDLVRTDRRGF
SCQEQSPFITAIDILRARRATGLMTRMGYQTITSVIRGEKQA

Download         Length: 369 bp

>T172055 NZ_CP079173:c14256-13906 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11551.11 Da        Isoelectric Point: 6.4700

>AT172055 WP_187962421.1 NZ_CP061082:1227338-1227649 [Serratia liquefaciens]
MTSINTPAWGLKRNVTPQFGARLVQEGKRLHFLADRADISGSFSEIQLRDVDNAFPQFINHLELMLLSGELNPSYQHCVT
RLTCEADSLGAHGYVYLSIYPTP

Download         Length: 312 bp

>AT172055 NZ_CP079173:c13901-13599 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References