Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1108125..1108752 Replicon chromosome
Accession NZ_CP061082
Organism Serratia liquefaciens strain MT49

Toxin (Protein)


Gene name Hha Uniprot ID A0A379ZYL4
Locus tag IAI46_RS05140 Protein ID WP_020825514.1
Coordinates 1108125..1108328 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A379ZYL8
Locus tag IAI46_RS05145 Protein ID WP_020825515.1
Coordinates 1108384..1108752 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI46_RS05125 1103682..1105025 - 1344 WP_187962358.1 NCS2 family permease -
IAI46_RS05130 1105190..1106977 - 1788 WP_187962359.1 amidohydrolase family protein -
IAI46_RS05135 1107116..1108048 + 933 WP_187962360.1 LysR family transcriptional regulator -
IAI46_RS05140 1108125..1108328 - 204 WP_020825514.1 hemolysin expression modulator Hha Toxin
IAI46_RS05145 1108384..1108752 - 369 WP_020825515.1 Hha toxicity modulator TomB Antitoxin
IAI46_RS05150 1108915..1109241 - 327 WP_187962936.1 hypothetical protein -
IAI46_RS05155 1109570..1109716 + 147 WP_020825517.1 hypothetical protein -
IAI46_RS05160 1109713..1110435 + 723 WP_176983628.1 ABC transporter ATP-binding protein -
IAI46_RS05165 1110422..1111279 + 858 WP_041414279.1 metal ABC transporter permease -
IAI46_RS05170 1111305..1112183 + 879 WP_020825520.1 metal ABC transporter substrate-binding protein -
IAI46_RS05175 1112296..1112436 - 141 WP_012005563.1 type B 50S ribosomal protein L36 -
IAI46_RS05180 1112449..1112703 - 255 WP_046374339.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1099073..1109268 10195


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9764

>T172054 WP_020825514.1 NZ_CP061082:c1108328-1108125 [Serratia liquefaciens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 204 bp

>T172054 NZ_CP079172:c5415299-5414916 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14189.89 Da        Isoelectric Point: 4.5140

>AT172054 WP_020825515.1 NZ_CP061082:c1108752-1108384 [Serratia liquefaciens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKS

Download         Length: 369 bp

>AT172054 NZ_CP079172:c5415541-5415299 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379ZYL4

Antitoxin

Source ID Structure
AlphaFold DB A0A379ZYL8

References