Detailed information of TA system TA172053

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 450029..450609
• Replicon: chromosome
• Accession: NZ_CP061082
• Organism: Serratia liquefaciens strain MT49

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IAI46_RS02125
• Protein ID: WP_187962183.1
• Coordinates: 450325..450609 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7W4F292
• Locus tag: IAI46_RS02120
• Protein ID: WP_020824985.1
• Coordinates: 450029..450316 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAI46_RS02095	445767..446852	-	1086	WP_048762826.1	carbon-phosphorus lyase complex subunit PhnI	-
IAI46_RS02100	446852..447433	-	582	WP_187962181.1	phosphonate C-P lyase system protein PhnH	-
IAI46_RS02105	447436..447879	-	444	WP_046374634.1	phosphonate C-P lyase system protein PhnG	-
IAI46_RS02110	447880..448608	-	729	WP_187962182.1	phosphonate metabolism transcriptional regulator PhnF	-
IAI46_RS02115	448866..449924	+	1059	WP_130016100.1	permease	-
IAI46_RS02120	450029..450316	+	288	WP_020824985.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IAI46_RS02125	450325..450609	+	285	WP_187962183.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAI46_RS02130	450606..451070	-	465	WP_046374631.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IAI46_RS02135	451244..453382	-	2139	WP_187962184.1	anaerobic ribonucleoside-triphosphate reductase	-
IAI46_RS02140	453666..454574	-	909	WP_187962185.1	LysR family transcriptional regulator	-
IAI46_RS02145	454679..455203	+	525	WP_187962186.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11145.82 Da
• Isoelectric Point: 4.7160

>T172053 WP_187962183.1 NZ_CP061082:450325-450609 [Serratia liquefaciens]
MRVEWDEEALRDRERIFDFLYPFNPQVAEQADAEIDKAVKRLLDYPELGKIWYRQARKLLVSQASLLVLYVVVDDVIKVL
AVAHQREKFPDIEN

Nucleotide

• Length: 285 bp

>T172053 NZ_CP079172:c4933780-4933496 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11043.40 Da
• Isoelectric Point: 6.4766

>AT172053 WP_020824985.1 NZ_CP061082:450029-450316 [Serratia liquefaciens]
MESRIQFRIEDETKRLAQKAAEAKGITLSEACRRLAEQMADEQRATEQHENWLKEKVDAAFARLHEGSAVYLDQQQVDES
MDAFKAKVRAKYDRK

Nucleotide

• Length: 288 bp

>AT172053 NZ_CP079172:c4934012-4933770 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F292