Detailed information of TA system TA172052

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 4416384..4417180
• Replicon: chromosome
• Accession: NZ_CP061081
• Organism: Marinomonas arctica strain BSI20414

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: IBG28_RS20450
• Protein ID: WP_111605908.1
• Coordinates: 4416758..4417180 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: IBG28_RS20445
• Protein ID: WP_111605909.1
• Coordinates: 4416384..4416761 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBG28_RS20430	4413592..4414296	-	705	WP_162623475.1	transporter substrate-binding domain-containing protein	-
IBG28_RS20435	4414617..4415336	-	720	WP_111605911.1	ribonuclease PH	-
IBG28_RS20440	4415495..4416361	+	867	WP_111605910.1	YicC family protein	-
IBG28_RS20445	4416384..4416761	+	378	WP_111605909.1	nucleotidyltransferase domain-containing protein	Antitoxin
IBG28_RS20450	4416758..4417180	+	423	WP_111605908.1	DUF86 domain-containing protein	Toxin
IBG28_RS20455	4417301..4418515	-	1215	WP_111605907.1	type II toxin-antitoxin system HipA family toxin	-
IBG28_RS20460	4418508..4418819	-	312	WP_111605906.1	helix-turn-helix transcriptional regulator	-
IBG28_RS20465	4419167..4420000	-	834	WP_111605905.1	ion transporter	-
IBG28_RS20470	4420254..4420388	+	135	WP_111605904.1	entericidin EcnAB	-
IBG28_RS20475	4420488..4422020	-	1533	WP_111605903.1	putative DNA binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (13-130)

Antitoxin

• Polymerase beta, nucleotidyltransferase (6-95)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15824.21 Da
• Isoelectric Point: 6.8621

>T172052 WP_111605908.1 NZ_CP061081:4416758-4417180 [Marinomonas arctica]
MNDSILNKLATIDRCLVRIRDVYALAKENFDTDYTSQDSIILNLQRACEASIDAANILNKQHQTGIPQSSRDSFELLKKA
GFIPAPLALNLQKMVGLRNIAVHDYQTLNLEIVKHVVEHRLSDFEEFVKAMKSLNLSNLV

Nucleotide

• Length: 423 bp

>T172052 NZ_CP079172:c4801789-4801256 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGATTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14121.22 Da
• Isoelectric Point: 4.2392

>AT172052 WP_111605909.1 NZ_CP061081:4416384-4416761 [Marinomonas arctica]
MLDRNKLIQAVKRLMPRARLIYLFGSQADGSATASSDIDIAVLLDKKMDSVARFDLQETLAIELNQDVDLIDLLAASTVL
QNQVIMNGELLFGSENEQAKFEMQIMSMYQHLNEERAGILQDYLQ

Nucleotide

• Length: 378 bp

>AT172052 NZ_CP079172:c4802066-4801800 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA