Detailed information of TA system TA172046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2759134..2759690
• Replicon: chromosome
• Accession: NZ_CP061081
• Organism: Marinomonas arctica strain BSI20414

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IBG28_RS12825
• Protein ID: WP_111607711.1
• Coordinates: 2759134..2759445 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1M5K658
• Locus tag: IBG28_RS12830
• Protein ID: WP_012069454.1
• Coordinates: 2759433..2759690 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBG28_RS12800	2754781..2755641	-	861	WP_111607716.1	DUF1853 family protein	-
IBG28_RS12805	2755638..2755979	-	342	WP_111607715.1	YqcC family protein	-
IBG28_RS12810	2756110..2757180	+	1071	WP_111607714.1	DUF3549 family protein	-
IBG28_RS12815	2757313..2757921	-	609	WP_111607713.1	TetR/AcrR family transcriptional regulator	-
IBG28_RS12820	2758015..2758896	+	882	WP_111607712.1	SDR family oxidoreductase	-
IBG28_RS12825	2759134..2759445	-	312	WP_111607711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IBG28_RS12830	2759433..2759690	-	258	WP_012069454.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IBG28_RS12835	2760009..2760707	-	699	WP_111607710.1	hypothetical protein	-
IBG28_RS12840	2760809..2761738	-	930	WP_111607709.1	hypothetical protein	-
IBG28_RS12845	2762131..2762550	-	420	WP_111607708.1	hypothetical protein	-
IBG28_RS12850	2762623..2763381	-	759	WP_111607744.1	carbon-nitrogen hydrolase family protein	-
IBG28_RS12855	2763545..2764309	-	765	WP_111607707.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12019.62 Da
• Isoelectric Point: 4.6412

>T172046 WP_111607711.1 NZ_CP061081:c2759445-2759134 [Marinomonas arctica]
MAQIIWTEPALNNLNDIAEYIAVSNPYAAKQLVENVFSKVQRLEQFPDSGRIPEEISTLNYREVVVNPCRVFYKVDSDSV
YILHLLRQERDLRKYLLSTTDEN

Nucleotide

• Length: 312 bp

>T172046 NZ_CP079172:335831-336199 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9778.46 Da
• Isoelectric Point: 8.5159

>AT172046 WP_012069454.1 NZ_CP061081:c2759690-2759433 [Marinomonas arctica]
MRTEVVTTLKRQATKLLADLRESKEPILITEHGQPSAYLLDVADYELMVERMKILEGIAKGEQAIREGRTMDMSQAKEKM
SKWLK

Nucleotide

• Length: 258 bp

>AT172046 NZ_CP079172:335613-335834 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1M5K658