172043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2481197..2481681 Replicon chromosome
Accession NZ_CP061081
Organism Marinomonas arctica strain BSI20414

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IBG28_RS11445 Protein ID WP_111607342.1
Coordinates 2481541..2481681 (-) Length 47 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IBG28_RS11440 Protein ID WP_111607343.1
Coordinates 2481197..2481544 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG28_RS11420 2478910..2479875 + 966 WP_111607346.1 cysteine synthase A -
IBG28_RS11425 2479993..2480241 - 249 WP_111607345.1 hypothetical protein -
IBG28_RS11430 2480333..2480734 - 402 WP_111607344.1 helix-turn-helix domain-containing protein -
IBG28_RS11435 2480736..2481092 - 357 WP_111607357.1 hypothetical protein -
IBG28_RS11440 2481197..2481544 - 348 WP_111607343.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IBG28_RS11445 2481541..2481681 - 141 WP_111607342.1 type II toxin-antitoxin system HicA family toxin Toxin
IBG28_RS11450 2481728..2482144 - 417 WP_111607341.1 hypothetical protein -
IBG28_RS11455 2482192..2482992 - 801 WP_111607340.1 class II glutamine amidotransferase -
IBG28_RS11460 2482985..2484856 - 1872 WP_111607339.1 VWA domain-containing protein -
IBG28_RS11465 2484906..2485385 - 480 WP_111607338.1 YcgN family cysteine cluster protein -
IBG28_RS11470 2485403..2485696 - 294 WP_111607337.1 YcgL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-40)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5235.21 Da        Isoelectric Point: 10.5720

>T172043 WP_111607342.1 NZ_CP061081:c2481681-2481541 [Marinomonas arctica]
MAGSRVRFYHKGKDAMLLLHKPHPENELKGGALKSVKLHLIQEGWL

Download         Length: 141 bp

>T172043 NZ_CP079164:3494080-3494397 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13198.97 Da        Isoelectric Point: 5.2522

>AT172043 WP_111607343.1 NZ_CP061081:c2481544-2481197 [Marinomonas arctica]
MTYLRYKDYLGTIEPELESNTLFGKLAFIRDTVTYEATTLKELEVEFRRSVDEYLLSCEELGREAQKPCKGSFNIRTGEA
LHREAVIAAEGQSLNAFVCDAIREKIAKMNHHHLD

Download         Length: 348 bp

>AT172043 NZ_CP079164:3494390-3494677 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References