172039

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-XRE
Location 574421..576057 Replicon chromosome
Accession NZ_CP061081
Organism Marinomonas arctica strain BSI20414

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag IBG28_RS02630 Protein ID WP_111608360.1
Coordinates 574741..576057 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag IBG28_RS02625 Protein ID WP_111608359.1
Coordinates 574421..574747 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG28_RS02600 569844..570437 - 594 WP_111608356.1 nucleoid occlusion factor SlmA -
IBG28_RS02605 570514..571422 - 909 WP_111608357.1 acetylglutamate kinase -
IBG28_RS02610 571743..572201 - 459 WP_011978451.1 dUTP diphosphatase -
IBG28_RS02615 572247..573464 - 1218 WP_111608376.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
IBG28_RS02620 573571..574245 + 675 WP_111608358.1 DNA repair protein RadC -
IBG28_RS02625 574421..574747 + 327 WP_111608359.1 helix-turn-helix domain-containing protein Antitoxin
IBG28_RS02630 574741..576057 + 1317 WP_111608360.1 type II toxin-antitoxin system HipA family toxin Toxin
IBG28_RS02635 576234..576470 + 237 WP_072838851.1 50S ribosomal protein L28 -
IBG28_RS02640 576482..576652 + 171 WP_011978459.1 50S ribosomal protein L33 -
IBG28_RS02645 576828..577646 + 819 WP_111608361.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
IBG28_RS02650 577900..578892 + 993 WP_111608362.1 BMP family ABC transporter substrate-binding protein -
IBG28_RS02655 578986..580542 + 1557 WP_111608363.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-117)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49344.14 Da        Isoelectric Point: 8.2375

>T172039 WP_111608360.1 NZ_CP061081:574741-576057 [Marinomonas arctica]
MVMEVIKVSYQGHDVGAVSFDVDKGIGAFEYTASFIKKGIELSPLKMPLSRRIFSFPELDFNTFKGLPGLIADSLPDNFG
NSVLNAWVASQGKSPNDISPLQRLQYTGKRGMGALEYSPATKLRSLNASQQVEIQSLVSIAQEILDSRGVFEVELNKDGR
EEREAMLSLLSVGMSAGGARPKAVLAFNKDFTQVRSGQTTVPEGFTHYLMKFDGVNEHNQNQETFGDPLGYGAMEFVYYL
MAESCGIEMMPCRLLEEGDRRHFITQRFDRVSNTKVHVQTLNGLAHVDYNKPGSFSYAEIFSVARQLKLPATDAQQILKR
MAFNIIARNHDDHAKNFAFILKNDRWSLAPAYDLAYSYKPGSKWVSSHWMSLNGKRDGFTRADFYSLQKLSPLFSKRKID
NVIDETIACVSQWRSLAQEWNVPRSLREEIQSNLRLSL

Download         Length: 1317 bp

>T172039 NZ_CP079164:2507471-2508388 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCATCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12018.05 Da        Isoelectric Point: 10.7033

>AT172039 WP_111608359.1 NZ_CP061081:574421-574747 [Marinomonas arctica]
MTIEKSSAALSEELGERLKQARLNLNLTQSEVAALAGVARKTVLNAEKGKVQLEVFVAIMIALNLTDQLNLFLPKQEISP
LQLAKLEGKKRQRASGVHREKNKGRLEW

Download         Length: 327 bp

>AT172039 NZ_CP079164:2506707-2507465 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References