Detailed information of TA system TA172038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 483174..483712
• Replicon: chromosome
• Accession: NZ_CP061081
• Organism: Marinomonas arctica strain BSI20414

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IBG28_RS02155
• Protein ID: WP_111608277.1
• Coordinates: 483174..483473 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: IBG28_RS02160
• Protein ID: WP_111608278.1
• Coordinates: 483470..483712 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBG28_RS02135	478572..479564	+	993	WP_111609084.1	helix-turn-helix domain-containing protein	-
IBG28_RS02140	479599..480561	-	963	WP_111609083.1	integron integrase	-
IBG28_RS02145	480645..481589	+	945	WP_188322991.1	IS1595 family transposase	-
IBG28_RS02150	481968..483074	+	1107	WP_111608276.1	nucleotide-binding protein	-
IBG28_RS02155	483174..483473	-	300	WP_111608277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IBG28_RS02160	483470..483712	-	243	WP_111608278.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
IBG28_RS02165	483993..484865	+	873	WP_111608279.1	DUF4394 domain-containing protein	-
IBG28_RS02170	485180..486382	+	1203	WP_111608370.1	zinc metallochaperone GTPase ZigA	-
IBG28_RS02175	486555..487058	+	504	WP_111608280.1	GNAT family N-acetyltransferase	-
IBG28_RS02180	487232..488227	-	996	WP_111608281.1	Abi family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	480645..481589	944

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (4-70)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11663.47 Da
• Isoelectric Point: 10.1368

>T172038 WP_111608277.1 NZ_CP061081:c483473-483174 [Marinomonas arctica]
MKPFRLTIKAKSDLKDIAVFTSRRWGREQRNIYLKQFDESFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYQQIGSQN
IQIIRILHKSMDVNPMFGA

Nucleotide

• Length: 300 bp

>T172038 NZ_CP079164:2194046-2194429 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8969.93 Da
• Isoelectric Point: 4.2340

>AT172038 WP_111608278.1 NZ_CP061081:c483712-483470 [Marinomonas arctica]
MAKNTSITLGEHFDSFISSQVQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGMADYDLDSLINELDNEEKK

Nucleotide

• Length: 243 bp

>AT172038 NZ_CP079164:2193804-2194046 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA