Detailed information of TA system TA172037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 268138..269786
• Replicon: chromosome
• Accession: NZ_CP061081
• Organism: Marinomonas arctica strain BSI20414

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IBG28_RS01135
• Protein ID: WP_111608478.1
• Coordinates: 268461..269786 (-)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IBG28_RS01130
• Protein ID: WP_111608479.1
• Coordinates: 268138..268464 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBG28_RS01110	264641..265417	-	777	WP_111608483.1	helix-turn-helix domain-containing protein	-
IBG28_RS01115	265436..266338	-	903	WP_111608482.1	MBL fold metallo-hydrolase	-
IBG28_RS01120	266518..267198	-	681	WP_111608481.1	monofunctional biosynthetic peptidoglycan transglycosylase	-
IBG28_RS01125	267401..268090	+	690	WP_111608480.1	metal-dependent hydrolase	-
IBG28_RS01130	268138..268464	-	327	WP_111608479.1	helix-turn-helix domain-containing protein	Antitoxin
IBG28_RS01135	268461..269786	-	1326	WP_111608478.1	type II toxin-antitoxin system HipA family toxin	Toxin
IBG28_RS01140	270006..270389	-	384	WP_111608477.1	STAS/SEC14 domain-containing protein	-
IBG28_RS01145	270668..271762	+	1095	WP_111608476.1	hypothetical protein	-
IBG28_RS01150	271799..271948	-	150	WP_111608537.1	DUF2256 domain-containing protein	-
IBG28_RS01155	272081..272830	-	750	WP_111608475.1	DUF481 domain-containing protein	-
IBG28_RS01160	273250..273597	-	348	WP_111608474.1	hypothetical protein	-
IBG28_RS01165	273601..274242	-	642	WP_111608473.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-370)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-71)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 50460.21 Da
• Isoelectric Point: 4.9269

>T172037 WP_111608478.1 NZ_CP061081:c269786-268461 [Marinomonas arctica]
MKTLTIQALTQQEWRDIAILKLLNPERGTASPSRLGYEFEYSVEWLDLNDERACSLVLPVQIMIEHEADHWFGFLEDIVP
AGAARRYLIDLWGLQTLSSSEQDTALLEKGTIAPVGNLRIKESLPTLPADSTLHLRKFTLHDVVERDSSFLEYAQEMGAI
SGGATGAGGEAPKLLVRCSAQGEIWIDTFQEQHDIADAHYLVKFPRGRKTRDDCDILRAEYHFYHELTDMGFNTISTEKM
KLLEGSRYPSLWLPRFDTHWNELNWERYGLESIFSVLNKPAGSYLNHFEVIRSVCNVLQKQSTEFDTARFVCEWLSRDLL
NIAFGNSDNHGRNTALLKKPNDIWLSPIYDFAPMKVDPEGITRTTKWGSPFEEGGEYRWQAITEELDDLCPYDTSFSALK
QTASKLIGLQQRLEARGVPERILEVIQVKWLETKLARWGLL

Nucleotide

• Length: 1326 bp

>T172037 NZ_CP079164:c1755802-1755434 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12022.10 Da
• Isoelectric Point: 10.5419

>AT172037 WP_111608479.1 NZ_CP061081:c268464-268138 [Marinomonas arctica]
MNMTASERQALLVELLQQHMLGGLTQGQMLKRLRKEVLGFSQTRYAELVGVSRRTLTDIEQDKGSQVQSIIDKVFKPLGM
KSGLTPIHPHVAKHIMAGTQLDGDLKVK

Nucleotide

• Length: 327 bp

>AT172037 NZ_CP079164:c1756020-1755799 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA