Detailed information of TA system TA172035

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 4443538..4444172
• Replicon: chromosome
• Accession: NZ_CP061080
• Organism: Mesirhizobium sp. NIBR3 strain N3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IAI54_RS20820
• Protein ID: WP_187969007.1
• Coordinates: 4443783..4444172 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IAI54_RS20815
• Protein ID: WP_187973270.1
• Coordinates: 4443538..4443786 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAI54_RS20800	4439253..4441166	+	1914	WP_187969004.1	twin-arginine translocation signal domain-containing protein	-
IAI54_RS20805	4441235..4442335	+	1101	WP_187969005.1	microcin C ABC transporter permease YejB	-
IAI54_RS20810	4442337..4443488	+	1152	WP_187969006.1	ABC transporter permease	-
IAI54_RS20815	4443538..4443786	+	249	WP_187973270.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
IAI54_RS20820	4443783..4444172	+	390	WP_187969007.1	type II toxin-antitoxin system VapC family toxin	Toxin
IAI54_RS20825	4444169..4445797	+	1629	WP_187969008.1	ABC transporter ATP-binding protein	-
IAI54_RS20830	4445824..4446771	+	948	WP_187969009.1	glyoxylate/hydroxypyruvate reductase A	-
IAI54_RS20835	4446784..4447647	-	864	WP_187969010.1	C40 family peptidase	-
IAI54_RS20840	4447644..4447997	-	354	WP_187969011.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (3-81)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14500.61 Da
• Isoelectric Point: 6.4751

>T172035 WP_187969007.1 NZ_CP061080:4443783-4444172 [Mesirhizobium sp. NIBR3]
MIVDASAILAVLFEEPEKDGFRDLMLRQKELAMSPVNYLEAAVRADDKRHPRKGVELDALLQGFGIAITVVDSRQAYLAR
EAYQRFGKGNHPARLNLGDCFAYALAKARREPLLFKGDDFRQTDVEAAF

Nucleotide

• Length: 390 bp

>T172035 NZ_CP079164:c99103-99001 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9063.33 Da
• Isoelectric Point: 6.7266

>AT172035 WP_187973270.1 NZ_CP061080:4443538-4443786 [Mesirhizobium sp. NIBR3]
VGMNIKDKEAHHLARMIADFTGESLTAAVVVALRERLERLERQADIAKRRALIDEIIRRSGPTAPGLSSDHSDLYDEAGL
PK

Nucleotide

• Length: 249 bp

>AT172035 NZ_CP079164:98994-99139 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT