Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3165242..3166041 Replicon chromosome
Accession NZ_CP061080
Organism Mesirhizobium sp. NIBR3 strain N3

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag IAI54_RS14795 Protein ID WP_187967934.1
Coordinates 3165242..3165733 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag IAI54_RS14800 Protein ID WP_210321129.1
Coordinates 3165730..3166041 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI54_RS14780 3161177..3162262 - 1086 WP_187967931.1 2'-deoxycytidine 5'-triphosphate deaminase -
IAI54_RS14785 3162481..3163668 + 1188 WP_187967932.1 O-succinylhomoserine sulfhydrylase -
IAI54_RS14790 3163762..3165234 + 1473 WP_187967933.1 hypothetical protein -
IAI54_RS14795 3165242..3165733 - 492 WP_187967934.1 GNAT family N-acetyltransferase Toxin
IAI54_RS14800 3165730..3166041 - 312 WP_210321129.1 DUF1778 domain-containing protein Antitoxin
IAI54_RS14805 3166084..3166689 - 606 WP_187967936.1 CDP-alcohol phosphatidyltransferase family protein -
IAI54_RS14810 3166821..3167213 + 393 WP_187967937.1 Co2+/Mg2+ efflux protein ApaG -
IAI54_RS14815 3167217..3168251 - 1035 WP_187967938.1 Hsp33 family molecular chaperone -
IAI54_RS14820 3168199..3169128 - 930 WP_187973164.1 ornithine carbamoyltransferase -
IAI54_RS14825 3169146..3170336 - 1191 WP_187967939.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(21-96)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17515.99 Da        Isoelectric Point: 9.0370

>T172033 WP_187967934.1 NZ_CP061080:c3165733-3165242 [Mesirhizobium sp. NIBR3]
VSLQAPGPLGEAHDFAAFASGADGLDDWLKRRARFNQASGASRTYVVADGTRVVGYCALASGAVVLSAASSRISRNMPDP
IPIVVFGRLAVDREWQGRGLGSAMFRDAAHRVRRAADTIGIRGMLVHAISEDARQFYLSLGFEPSMLDPMTLLVRLADIE
TAR

Download         Length: 492 bp

>T172033 NZ_CP079156:c245372-244890 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11738.39 Da        Isoelectric Point: 9.3372

>AT172033 WP_210321129.1 NZ_CP061080:c3166041-3165730 [Mesirhizobium sp. NIBR3]
MTMQPTSKPTEKVSRPVRDTLNLRIRPDLRSLIDQAAELAGKSRSDFVLEASRRAAEETLRDRTLWLADPDAFAAFCERL
DLPSAPSERLRHVLARKAPWEQP

Download         Length: 312 bp

>AT172033 NZ_CP079156:c245641-245363 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References