172032

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2280133..2280679 Replicon chromosome
Accession NZ_CP061080
Organism Mesirhizobium sp. NIBR3 strain N3

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag IAI54_RS10580 Protein ID WP_187972301.1
Coordinates 2280425..2280679 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag IAI54_RS10575 Protein ID WP_187972300.1
Coordinates 2280133..2280438 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI54_RS10555 2276171..2276731 - 561 WP_187973110.1 TRAP transporter small permease -
IAI54_RS10560 2277075..2278172 - 1098 WP_187972297.1 TRAP transporter substrate-binding protein -
IAI54_RS10565 2278293..2278754 - 462 WP_187972298.1 Lrp/AsnC family transcriptional regulator -
IAI54_RS10570 2278902..2280014 + 1113 WP_187972299.1 4-hydroxyphenylpyruvate dioxygenase -
IAI54_RS10575 2280133..2280438 - 306 WP_187972300.1 BrnA antitoxin family protein Antitoxin
IAI54_RS10580 2280425..2280679 - 255 WP_187972301.1 BrnT family toxin Toxin
IAI54_RS10585 2280734..2280997 - 264 WP_187972302.1 hypothetical protein -
IAI54_RS10590 2281019..2281312 - 294 WP_187972303.1 hypothetical protein -
IAI54_RS10595 2281379..2282392 - 1014 WP_187972304.1 fumarylacetoacetate hydrolase family protein -
IAI54_RS10600 2282501..2282959 + 459 WP_187972305.1 MarR family transcriptional regulator -
IAI54_RS10605 2283024..2283590 + 567 WP_187972306.1 lipocalin family protein -
IAI54_RS10610 2283690..2283947 + 258 WP_187972307.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
IAI54_RS10615 2283948..2284349 + 402 WP_187972308.1 type II toxin-antitoxin system VapC family toxin -
IAI54_RS10620 2284353..2285387 - 1035 WP_187972309.1 L-threonine 3-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-77)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(26-97)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9384.79 Da        Isoelectric Point: 7.0112

>T172032 WP_187972301.1 NZ_CP061080:c2280679-2280425 [Mesirhizobium sp. NIBR3]
MRILWDEPKRLANIDKHGLDFSALTEDFFASAVIRVARGERYLAVGELSSFFVAVVFRPLGAEALSVISMRPANRKETPP
YDAS

Download         Length: 255 bp

>T172032 NZ_CP079156:167930-168400 [Klebsiella pneumoniae subsp. pneumoniae]
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11454.84 Da        Isoelectric Point: 8.6343

>AT172032 WP_187972300.1 NZ_CP061080:c2280438-2280133 [Mesirhizobium sp. NIBR3]
MTPRKLQAEFKPGRGYSREDWDAVSDNPEWTEEDFARARPFADVFPELAASIRRGRPPVENPKKQVTLRLDADVVERFRA
GGPGWQSRMNEALRKAAGLAD

Download         Length: 306 bp

>AT172032 NZ_CP079156:167490-167933 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References