Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2241731..2242293 Replicon chromosome
Accession NZ_CP061080
Organism Mesirhizobium sp. NIBR3 strain N3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IAI54_RS10395 Protein ID WP_187972270.1
Coordinates 2241925..2242293 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IAI54_RS10390 Protein ID WP_187972269.1
Coordinates 2241731..2241928 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI54_RS10370 2237428..2239275 - 1848 WP_187972265.1 ABC transporter ATP-binding protein/permease -
IAI54_RS10375 2239806..2240255 + 450 WP_187972266.1 tRNA methyltransferase -
IAI54_RS10380 2240266..2240526 - 261 WP_187972267.1 hypothetical protein -
IAI54_RS10385 2240759..2241673 + 915 WP_187972268.1 oxygen-dependent coproporphyrinogen oxidase -
IAI54_RS10390 2241731..2241928 + 198 WP_187972269.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IAI54_RS10395 2241925..2242293 + 369 WP_187972270.1 type II toxin-antitoxin system VapC family toxin Toxin
IAI54_RS10400 2242397..2242582 + 186 WP_187972271.1 DUF1059 domain-containing protein -
IAI54_RS10405 2242737..2244008 - 1272 WP_187972272.1 CCA tRNA nucleotidyltransferase -
IAI54_RS10410 2244005..2244634 - 630 WP_187972273.1 CoA pyrophosphatase -
IAI54_RS10415 2244637..2245305 - 669 WP_187973106.1 DUF1285 domain-containing protein -
IAI54_RS10420 2245450..2246457 + 1008 WP_187972274.1 MoxR family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13781.05 Da        Isoelectric Point: 5.8929

>T172031 WP_187972270.1 NZ_CP061080:2241925-2242293 [Mesirhizobium sp. NIBR3]
MILVDSVIWVDHIRQELPRLSRLLDNGETLCHPFVVGEIALGSLRDRQFVLESLSSLPQAPLAEHEEVLFLLEERKLFSL
GIGYVDLHLVASCLLAPGTLLWTRDRRLDAAAYHLGIKYLHG

Download         Length: 369 bp

>T172031 NZ_CP079156:23293-23577 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7182.17 Da        Isoelectric Point: 6.3085

>AT172031 WP_187972269.1 NZ_CP061080:2241731-2241928 [Mesirhizobium sp. NIBR3]
VRTTVTLDDVLLEQAQRFSGINERSALIEAALKALVEREAARRLAKLGGSQPDLEIPDRRRPAAE

Download         Length: 198 bp

>AT172031 NZ_CP079156:23055-23303 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References