Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2087201..2087678 Replicon chromosome
Accession NZ_CP061080
Organism Mesirhizobium sp. NIBR3 strain N3

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag IAI54_RS09615 Protein ID WP_187972132.1
Coordinates 2087201..2087467 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag IAI54_RS09620 Protein ID WP_187972133.1
Coordinates 2087451..2087678 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI54_RS09590 2083817..2084089 + 273 WP_187972129.1 BrnT family toxin -
IAI54_RS09595 2084067..2084291 + 225 WP_210321229.1 CopG family transcriptional regulator -
IAI54_RS09600 2084292..2085461 - 1170 WP_187972130.1 MFS transporter -
IAI54_RS09605 2085458..2086558 - 1101 WP_187973089.1 3-carboxy-cis,cis-muconate cycloisomerase -
IAI54_RS09610 2086574..2087185 - 612 WP_187972131.1 protocatechuate 3,4-dioxygenase subunit alpha -
IAI54_RS09615 2087201..2087467 - 267 WP_187972132.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IAI54_RS09620 2087451..2087678 - 228 WP_187972133.1 ribbon-helix-helix protein, CopG family Antitoxin
IAI54_RS09625 2087741..2088499 - 759 WP_187972134.1 protocatechuate 3,4-dioxygenase subunit beta -
IAI54_RS09630 2088496..2088897 - 402 WP_187972135.1 4-carboxymuconolactone decarboxylase -
IAI54_RS09635 2089001..2089945 + 945 WP_187972136.1 pca operon transcription factor PcaQ -
IAI54_RS09640 2089924..2091096 - 1173 WP_187972137.1 4-hydroxybenzoate 3-monooxygenase -
IAI54_RS09645 2091245..2092129 + 885 WP_187973090.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10273.95 Da        Isoelectric Point: 10.3110

>T172030 WP_187972132.1 NZ_CP061080:c2087467-2087201 [Mesirhizobium sp. NIBR3]
MAWTIELSDTAKKSLRKLDRQVSKRIAEFLRGRVALLDNPRTLGKALHASLENYWSYRVGDYRLVCEIRDKTLVVLVVEI
GHRSDIYR

Download         Length: 267 bp

>T172030 NZ_CP079155:4805942-4807264 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8730.76 Da        Isoelectric Point: 4.2403

>AT172030 WP_187972133.1 NZ_CP061080:c2087678-2087451 [Mesirhizobium sp. NIBR3]
MPTSIRLEPEIEARLDALAARTGRTKAYYLRQLITEGLDDLEDYYTAVEVSERIRRGEERTYPLEEVIRDLGLDD

Download         Length: 228 bp

>AT172030 NZ_CP079155:4805676-4805942 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References