Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 137335..138188 Replicon chromosome
Accession NZ_CP061080
Organism Mesirhizobium sp. NIBR3 strain N3

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag IAI54_RS00645 Protein ID WP_187970545.1
Coordinates 137652..138188 (+) Length 179 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag IAI54_RS00640 Protein ID WP_187970544.1
Coordinates 137335..137664 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI54_RS00605 132934..133359 + 426 WP_187972952.1 VOC family protein -
IAI54_RS00610 133477..134280 + 804 WP_187970538.1 hypothetical protein -
IAI54_RS00615 134308..134829 + 522 WP_187970539.1 CoA-binding protein -
IAI54_RS00620 134987..136270 + 1284 WP_187970540.1 O-acetylhomoserine aminocarboxypropyltransferase -
IAI54_RS00625 136275..136619 + 345 WP_187970541.1 cupin domain-containing protein -
IAI54_RS00630 136644..136880 + 237 WP_187970542.1 DUF4160 domain-containing protein -
IAI54_RS00635 136861..137133 + 273 WP_187970543.1 DUF2442 domain-containing protein -
IAI54_RS00640 137335..137664 + 330 WP_187970544.1 DUF1778 domain-containing protein Antitoxin
IAI54_RS00645 137652..138188 + 537 WP_187970545.1 GNAT family N-acetyltransferase Toxin
IAI54_RS00650 138210..139445 - 1236 WP_187970546.1 cytochrome P450 -
IAI54_RS00655 139565..140374 - 810 WP_210321194.1 class D beta-lactamase -
IAI54_RS00660 140493..141596 + 1104 WP_187970547.1 FAD-dependent oxidoreductase -
IAI54_RS00665 141736..142368 + 633 WP_187970548.1 ATP-dependent Clp protease proteolytic subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(49-151)

Antitoxin

Vibrio phage ICP1, Orf50

(28-104)


Sequences

Toxin        


Download         Length: 179 a.a.        Molecular weight: 19200.75 Da        Isoelectric Point: 6.8486

>T172028 WP_187970545.1 NZ_CP061080:137652-138188 [Mesirhizobium sp. NIBR3]
MAEIGEASRGGENGLSAPVPLTADHDPSEFDCGEPALNDWLRHRALKNESRFSRTYVVCEGNRVVGYFCILAGAVERGAA
PSRVRRNAPDTIPVSVIGRLAVDKAHAGKGLGTDILSDALRRIALASRSIGIGAVLVHAKDDAARRFYRRCAEFIEYPDD
SRTLFLPIETVVAALSPD

Download         Length: 537 bp

>T172028 NZ_CP079155:c3433289-3433071 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12235.08 Da        Isoelectric Point: 9.9842

>AT172028 WP_187970544.1 NZ_CP061080:137335-137664 [Mesirhizobium sp. NIBR3]
MTRVPSPRSPVLDDVAVAERSTETKGSINLRIEANTRQLIDDAAAVLGKTRTEFMVETARREAIDVLLDQRLFVLDPERY
GAFMHALDNPPAPGPKLRSLLRRVPAWQK

Download         Length: 330 bp

>AT172028 NZ_CP079155:c3433690-3433316 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References