Detailed information of TA system TA172027

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 6061062..6061651
• Replicon: chromosome
• Accession: NZ_CP061079
• Organism: Pseudomonas chlororaphis strain qlu-1

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: HLB40_RS26865
• Protein ID: WP_028683468.1
• Coordinates: 6061352..6061651 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: HLB40_RS26860
• Protein ID: WP_007924096.1
• Coordinates: 6061062..6061355 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB40_RS26840	6056603..6057766	-	1164	WP_101283689.1	acyltransferase	-
HLB40_RS26845	6057961..6059151	-	1191	WP_028683472.1	serine hydrolase	-
HLB40_RS26850	6059278..6060165	+	888	WP_009051074.1	LysR family transcriptional regulator	-
HLB40_RS26855	6060537..6060929	+	393	WP_028683470.1	hypothetical protein	-
HLB40_RS26860	6061062..6061355	-	294	WP_007924096.1	putative addiction module antidote protein	Antitoxin
HLB40_RS26865	6061352..6061651	-	300	WP_028683468.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HLB40_RS26870	6061822..6062271	+	450	WP_009051078.1	DUF3828 domain-containing protein	-
HLB40_RS26875	6062296..6063306	-	1011	WP_188056704.1	NAD(P)-dependent alcohol dehydrogenase	-
HLB40_RS26880	6063364..6063663	-	300	WP_009051080.1	ArsR family transcriptional regulator	-
HLB40_RS26885	6063727..6064818	-	1092	WP_009051081.1	nitrite reductase, copper-containing	-
HLB40_RS26890	6065079..6065321	-	243	WP_009051082.1	hypothetical protein	-
HLB40_RS26895	6065807..6066049	+	243	WP_007924102.1	exodeoxyribonuclease VII small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-96)

Antitoxin

• Uncharacterized protein HI1420 (6-91)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11256.97 Da
• Isoelectric Point: 10.4277

>T172027 WP_028683468.1 NZ_CP061079:c6061651-6061352 [Pseudomonas chlororaphis]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQQLGSQLVILLCGGDKS
RQSRDIELAKYLARRWSRS

Nucleotide

• Length: 300 bp

>T172027 NZ_CP079155:2838581-2839114 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10430.94 Da
• Isoelectric Point: 5.6558

>AT172027 WP_007924096.1 NZ_CP061079:c6061355-6061062 [Pseudomonas chlororaphis]
MNEPLFDYDPATALRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Nucleotide

• Length: 294 bp

>AT172027 NZ_CP079155:2838304-2838570 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA