172023

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1505096..1505624 Replicon chromosome
Accession NZ_CP061079
Organism Pseudomonas chlororaphis strain qlu-1

Toxin (Protein)


Gene name relE Uniprot ID A0A7S5LMJ4
Locus tag HLB40_RS06785 Protein ID WP_038581545.1
Coordinates 1505096..1505395 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7S5HLJ1
Locus tag HLB40_RS06790 Protein ID WP_038581543.1
Coordinates 1505385..1505624 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB40_RS06765 1501003..1501785 - 783 WP_101281929.1 aldolase -
HLB40_RS06770 1501945..1502487 + 543 WP_007922237.1 XRE family transcriptional regulator -
HLB40_RS06775 1502697..1503716 - 1020 WP_009047445.1 DUF4917 family protein -
HLB40_RS06780 1503874..1505022 + 1149 WP_038630803.1 L-threonine dehydrogenase -
HLB40_RS06785 1505096..1505395 - 300 WP_038581545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HLB40_RS06790 1505385..1505624 - 240 WP_038581543.1 ribbon-helix-helix protein, CopG family Antitoxin
HLB40_RS06795 1505761..1506177 + 417 WP_101281930.1 fosfomycin resistance glutathione transferase -
HLB40_RS06800 1506305..1506943 + 639 WP_016702101.1 LysE family translocator -
HLB40_RS06805 1507055..1508395 + 1341 WP_101281931.1 sensor domain-containing diguanylate cyclase -
HLB40_RS06810 1508535..1509059 + 525 WP_009047451.1 DUF4142 domain-containing protein -
HLB40_RS06815 1509153..1510043 - 891 WP_101284080.1 phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-82)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11487.13 Da        Isoelectric Point: 10.8916

>T172023 WP_038581545.1 NZ_CP061079:c1505395-1505096 [Pseudomonas chlororaphis]
MHVEWLRSALKNLDDEAAYIAQDSPQAAAEFVKAILSSIQHLSRFPASGREGRLPGTREWVVPNRPYLIPYRVRQGRLQI
LRIFHTRRLPPAGWQDDRQ

Download         Length: 300 bp

>T172023 NZ_CP079155:c1822165-1821797 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8648.73 Da        Isoelectric Point: 4.5535

>AT172023 WP_038581543.1 NZ_CP061079:c1505624-1505385 [Pseudomonas chlororaphis]
MSVMSLRLPDDVADTLAHLAKATGRSKSFLAVDALREYLAREAWQINEIQKALTEAEAGDFASAEELDGVLNKWTGNAR

Download         Length: 240 bp

>AT172023 NZ_CP079155:c1822383-1822162 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S5LMJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7S5HLJ1

References