Detailed information of TA system TA172021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 202616..203132
• Replicon: chromosome
• Accession: NZ_CP061079
• Organism: Pseudomonas chlororaphis strain qlu-1

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A285EY61
• Locus tag: HLB40_RS00855
• Protein ID: WP_009041601.1
• Coordinates: 202851..203132 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A554PKE4
• Locus tag: HLB40_RS00850
• Protein ID: WP_009046356.1
• Coordinates: 202616..202861 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB40_RS00825	198384..199379	+	996	WP_101281621.1	sulfotransferase family protein	-
HLB40_RS00830	199345..200103	-	759	WP_009046352.1	slipin family protein	-
HLB40_RS00835	200105..201490	-	1386	WP_009046353.1	nodulation protein NfeD	-
HLB40_RS00840	201714..202175	+	462	WP_016705004.1	YbaK/EbsC family protein	-
HLB40_RS00845	202306..202551	+	246	WP_009046355.1	DUF2789 domain-containing protein	-
HLB40_RS00850	202616..202861	+	246	WP_009046356.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HLB40_RS00855	202851..203132	+	282	WP_009041601.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HLB40_RS00860	203265..203693	+	429	WP_028681511.1	winged helix DNA-binding protein	-
HLB40_RS00865	203690..205774	+	2085	WP_101281622.1	FUSC family protein	-
HLB40_RS00870	205771..205980	+	210	WP_007932080.1	DUF1656 domain-containing protein	-
HLB40_RS00875	205977..206873	+	897	WP_101281623.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10879.81 Da
• Isoelectric Point: 10.5797

>T172021 WP_009041601.1 NZ_CP061079:202851-203132 [Pseudomonas chlororaphis]
MTYKLQFLPSARKEWDKLGHTLREQFKKKLAERLEMPRVPADALHGMADCYKIKLKASGYRLVYQVIEDQVVVSVVAVGK
RERSAVYERARKR

Nucleotide

• Length: 282 bp

>T172021 NZ_CP079155:c99103-99001 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8814.14 Da
• Isoelectric Point: 4.7164

>AT172021 WP_009046356.1 NZ_CP061079:202616-202861 [Pseudomonas chlororaphis]
MQSVLADKAVSVSELKKNPSAVLNGAQGGAVAVLNHNRVMGYMVPADVFEAMMERLDDLELAEIVRARRHETPVPVNLDD
L

Nucleotide

• Length: 246 bp

>AT172021 NZ_CP079155:98994-99139 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: A0A285EY61

Antitoxin

• AlphaFold DB: A0A554PKE4