Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3384795..3385300 Replicon chromosome
Accession NZ_CP061073
Organism Pseudomonas aeruginosa strain PAD8

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag IBG29_RS15725 Protein ID WP_003083773.1
Coordinates 3384795..3385076 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag IBG29_RS15730 Protein ID WP_003112628.1
Coordinates 3385073..3385300 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG29_RS15700 (IBG29_18370) 3380046..3381395 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
IBG29_RS15705 (IBG29_18365) 3381444..3382130 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
IBG29_RS15710 (IBG29_18360) 3382231..3382965 + 735 WP_003117208.1 GntR family transcriptional regulator -
IBG29_RS15715 (IBG29_18355) 3383145..3383555 + 411 WP_003101225.1 aegerolysin family protein -
IBG29_RS15720 (IBG29_18350) 3383587..3384495 - 909 WP_023132709.1 LysR family transcriptional regulator -
IBG29_RS15725 (IBG29_18345) 3384795..3385076 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
IBG29_RS15730 (IBG29_18340) 3385073..3385300 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
IBG29_RS15735 (IBG29_18335) 3385476..3386096 - 621 WP_003101226.1 hypothetical protein -
IBG29_RS15740 (IBG29_18330) 3386197..3386697 + 501 WP_003101228.1 LEA type 2 family protein -
IBG29_RS15745 (IBG29_18325) 3386770..3387111 + 342 WP_034003659.1 zinc ribbon domain-containing protein YjdM -
IBG29_RS15750 (IBG29_18320) 3387193..3388620 - 1428 WP_003083784.1 GABA permease -
IBG29_RS15755 (IBG29_18315) 3388789..3390282 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T172017 WP_003083773.1 NZ_CP061073:c3385076-3384795 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T172017 NZ_CP079151:23293-23577 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT172017 WP_003112628.1 NZ_CP061073:c3385300-3385073 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT172017 NZ_CP079151:23055-23303 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References