Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5681102..5681666 Replicon chromosome
Accession NZ_CP061072
Organism Streptomyces sp. CB00271

Toxin (Protein)


Gene name mazF Uniprot ID A0A7H0NPE0
Locus tag HYC88_RS24370 Protein ID WP_073801308.1
Coordinates 5681319..5681666 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7H0NPD9
Locus tag HYC88_RS24365 Protein ID WP_073801307.1
Coordinates 5681102..5681332 (+) Length 77 a.a.

Genomic Context

HYC88_RS24355HYC88_RS24365HYC88_RS24370HYC88_RS24360HYC88_RS24375HYC88_RS24380
Location: 5677411..5678334 (924 bp)
Type: Others
Protein ID: WP_007455095.1
Location: 5681102..5681332 (231 bp)
Type: Antitoxin
Protein ID: WP_073801307.1
Location: 5681319..5681666 (348 bp)
Type: Toxin
Protein ID: WP_073801308.1
Location: 5678422..5680998 (2577 bp)
Type: Others
Protein ID: WP_073802178.1
Location: 5681743..5682771 (1029 bp)
Type: Others
Protein ID: WP_073801310.1
Location: 5683062..5686370 (3309 bp)
Type: Others
Protein ID: WP_188114985.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HYC88_RS243555677411..5678334+924WP_007455095.1LysR family transcriptional regulator-
HYC88_RS243605678422..5680998-2577WP_073802178.1aminopeptidase N-
HYC88_RS243655681102..5681332+231WP_073801307.1ribbon-helix-helix domain-containing proteinAntitoxin
HYC88_RS243705681319..5681666+348WP_073801308.1type II toxin-antitoxin system PemK/MazF family toxinToxin
HYC88_RS243755681743..5682771-1029WP_073801310.1aspartate-semialdehyde dehydrogenase-
HYC88_RS243805683062..5686370-3309WP_188114985.1S8 family serine peptidase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12696.56 Da        Isoelectric Point: 10.3399

>T172013 WP_073801308.1 NZ_CP061072:5681319-5681666 [Streptomyces sp. CB00271]
MRRGDVYLVDYEPVRGSEANKARPSVIISNDGANAAVDRTGRGVVTVVPLTSNTSRVYPFQVLLQASDCGLAKDSKAQCE
QVRAMAQERFLRQIGKVPRQRMAEIDAALRRHLAL

Download         Length: 348 bp

>T172013 NZ_CP079150:c4785138-4784605 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8441.16 Da        Isoelectric Point: 3.7661

>AT172013 WP_073801307.1 NZ_CP061072:5681102-5681332 [Streptomyces sp. CB00271]
MKISVSLPQEDVAFVDEYAAKIDADSRSAVIHAAIELLRASNLEADYVEAFAEWDESEDAEFWDKFSGDGIADEAR

Download         Length: 231 bp

>AT172013 NZ_CP079150:c4785415-4785149 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7H0NPE0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7H0NPD9

References