Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5681102..5681666 Replicon chromosome
Accession NZ_CP061072
Organism Streptomyces sp. CB00271

Toxin (Protein)


Gene name mazF Uniprot ID A0A7H0NPE0
Locus tag HYC88_RS24370 Protein ID WP_073801308.1
Coordinates 5681319..5681666 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7H0NPD9
Locus tag HYC88_RS24365 Protein ID WP_073801307.1
Coordinates 5681102..5681332 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYC88_RS24355 5677411..5678334 + 924 WP_007455095.1 LysR family transcriptional regulator -
HYC88_RS24360 5678422..5680998 - 2577 WP_073802178.1 aminopeptidase N -
HYC88_RS24365 5681102..5681332 + 231 WP_073801307.1 ribbon-helix-helix domain-containing protein Antitoxin
HYC88_RS24370 5681319..5681666 + 348 WP_073801308.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HYC88_RS24375 5681743..5682771 - 1029 WP_073801310.1 aspartate-semialdehyde dehydrogenase -
HYC88_RS24380 5683062..5686370 - 3309 WP_188114985.1 S8 family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12696.56 Da        Isoelectric Point: 10.3399

>T172013 WP_073801308.1 NZ_CP061072:5681319-5681666 [Streptomyces sp. CB00271]
MRRGDVYLVDYEPVRGSEANKARPSVIISNDGANAAVDRTGRGVVTVVPLTSNTSRVYPFQVLLQASDCGLAKDSKAQCE
QVRAMAQERFLRQIGKVPRQRMAEIDAALRRHLAL

Download         Length: 348 bp

>T172013 NZ_CP079150:c4785138-4784605 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8441.16 Da        Isoelectric Point: 3.7661

>AT172013 WP_073801307.1 NZ_CP061072:5681102-5681332 [Streptomyces sp. CB00271]
MKISVSLPQEDVAFVDEYAAKIDADSRSAVIHAAIELLRASNLEADYVEAFAEWDESEDAEFWDKFSGDGIADEAR

Download         Length: 231 bp

>AT172013 NZ_CP079150:c4785415-4785149 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0NPE0

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0NPD9

References