Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3339777..3340450 Replicon chromosome
Accession NZ_CP061072
Organism Streptomyces sp. CB00271

Toxin (Protein)


Gene name vapC Uniprot ID A0A7K3R411
Locus tag HYC88_RS14220 Protein ID WP_073800430.1
Coordinates 3340016..3340450 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7H0NJE1
Locus tag HYC88_RS14215 Protein ID WP_073800431.1
Coordinates 3339777..3340019 (+) Length 81 a.a.

Genomic Context

HYC88_RS14210HYC88_RS14215HYC88_RS14220HYC88_RS14230HYC88_RS14195HYC88_RS14200HYC88_RS14205HYC88_RS14225
Location: 3338747..3339700 (954 bp)
Type: Others
Protein ID: WP_073800432.1
Location: 3339777..3340019 (243 bp)
Type: Antitoxin
Protein ID: WP_073800431.1
Location: 3340016..3340450 (435 bp)
Type: Toxin
Protein ID: WP_073800430.1
Location: 3341713..3342603 (891 bp)
Type: Others
Protein ID: WP_073800428.1
Location: 3335266..3337008 (1743 bp)
Type: Others
Protein ID: WP_073800435.1
Location: 3337005..3337811 (807 bp)
Type: Others
Protein ID: WP_073800434.1
Location: 3337994..3338638 (645 bp)
Type: Others
Protein ID: WP_073800433.1
Location: 3340482..3341453 (972 bp)
Type: Others
Protein ID: WP_073800429.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HYC88_RS141953335266..3337008-1743WP_073800435.1DUF1446 domain-containing protein-
HYC88_RS142003337005..3337811-807WP_073800434.1TIGR03084 family protein-
HYC88_RS142053337994..3338638-645WP_073800433.1TetR family transcriptional regulator-
HYC88_RS142103338747..3339700+954WP_073800432.1SDR family oxidoreductase-
HYC88_RS142153339777..3340019+243WP_073800431.1ribbon-helix-helix domain-containing proteinAntitoxin
HYC88_RS142203340016..3340450+435WP_073800430.1PIN domain-containing proteinToxin
HYC88_RS142253340482..3341453-972WP_073800429.1EamA family transporter-
HYC88_RS142303341713..3342603+891WP_073800428.1LysR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-40)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 16166.40 Da        Isoelectric Point: 4.4863

>T172012 WP_073800430.1 NZ_CP061072:3340016-3340450 [Streptomyces sp. CB00271]
MIIVADTSALYAAFDAAQAEHPEAARILENERLAISPLVVTELDHLVHRDLGFPAAMQVMEALNSRMDDGQYRLAELRLA
DLRTAQEVRQKYEGLRLDLADAVGVVLADRYRTDRIFTLDQRDFRAMSPLTPGLDAFRILPADD

Download         Length: 435 bp

>T172012 NZ_CP079150:4190430-4190648 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9158.38 Da        Isoelectric Point: 5.8769

>AT172012 WP_073800431.1 NZ_CP061072:3339777-3340019 [Streptomyces sp. CB00271]
MIKTTVYLPEELEVRLDAESSATGVSKAELIRRSIALLLDSAERPKRTRQLPVFDSGRSLTPDEMDDSVYEHIKERNARR

Download         Length: 243 bp

>AT172012 NZ_CP079150:4190029-4190403 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7K3R411

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7H0NJE1

References