Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3339777..3340450 Replicon chromosome
Accession NZ_CP061072
Organism Streptomyces sp. CB00271

Toxin (Protein)


Gene name vapC Uniprot ID A0A7K3R411
Locus tag HYC88_RS14220 Protein ID WP_073800430.1
Coordinates 3340016..3340450 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7H0NJE1
Locus tag HYC88_RS14215 Protein ID WP_073800431.1
Coordinates 3339777..3340019 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYC88_RS14195 3335266..3337008 - 1743 WP_073800435.1 DUF1446 domain-containing protein -
HYC88_RS14200 3337005..3337811 - 807 WP_073800434.1 TIGR03084 family protein -
HYC88_RS14205 3337994..3338638 - 645 WP_073800433.1 TetR family transcriptional regulator -
HYC88_RS14210 3338747..3339700 + 954 WP_073800432.1 SDR family oxidoreductase -
HYC88_RS14215 3339777..3340019 + 243 WP_073800431.1 ribbon-helix-helix domain-containing protein Antitoxin
HYC88_RS14220 3340016..3340450 + 435 WP_073800430.1 PIN domain-containing protein Toxin
HYC88_RS14225 3340482..3341453 - 972 WP_073800429.1 EamA family transporter -
HYC88_RS14230 3341713..3342603 + 891 WP_073800428.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-40)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 16166.40 Da        Isoelectric Point: 4.4863

>T172012 WP_073800430.1 NZ_CP061072:3340016-3340450 [Streptomyces sp. CB00271]
MIIVADTSALYAAFDAAQAEHPEAARILENERLAISPLVVTELDHLVHRDLGFPAAMQVMEALNSRMDDGQYRLAELRLA
DLRTAQEVRQKYEGLRLDLADAVGVVLADRYRTDRIFTLDQRDFRAMSPLTPGLDAFRILPADD

Download         Length: 435 bp

>T172012 NZ_CP079150:4190430-4190648 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9158.38 Da        Isoelectric Point: 5.8769

>AT172012 WP_073800431.1 NZ_CP061072:3339777-3340019 [Streptomyces sp. CB00271]
MIKTTVYLPEELEVRLDAESSATGVSKAELIRRSIALLLDSAERPKRTRQLPVFDSGRSLTPDEMDDSVYEHIKERNARR

Download         Length: 243 bp

>AT172012 NZ_CP079150:4190029-4190403 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7K3R411

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0NJE1

References