Detailed information of TA system TA172011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 719547..720133
• Replicon: chromosome
• Accession: NZ_CP061071
• Organism: Streptococcus mutans B04Sm5

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IBL27_RS03645
• Protein ID: WP_002265423.1
• Coordinates: 719547..719738 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0H5AQZ7
• Locus tag: IBL27_RS03650
• Protein ID: WP_002269450.1
• Coordinates: 719756..720133 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBL27_RS03630	717591..718457	+	867	WP_002264919.1	type II CRISPR-associated endonuclease Cas1	-
IBL27_RS03635	718454..718798	+	345	WP_002308624.1	CRISPR-associated endonuclease Cas2	-
IBL27_RS03640	718788..719450	+	663	WP_002263546.1	type II-A CRISPR-associated protein Csn2	-
IBL27_RS03645	719547..719738	+	192	WP_002265423.1	type II toxin-antitoxin system HicA family toxin	Toxin
IBL27_RS03650	719756..720133	+	378	WP_002269450.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IBL27_RS03655	720669..721562	-	894	WP_002272311.1	LexA family transcriptional regulator IrvR	-
IBL27_RS03660	721878..722162	+	285	WP_002278032.1	helix-turn-helix transcriptional regulator	-
IBL27_RS03665	722325..724076	+	1752	WP_024784392.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7177.52 Da
• Isoelectric Point: 10.7089

>T172011 WP_002265423.1 NZ_CP061071:719547-719738 [Streptococcus mutans B04Sm5]
MPLTGKELARLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T172011 NZ_CP079150:c4066264-4065947 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14293.28 Da
• Isoelectric Point: 4.5628

>AT172011 WP_002269450.1 NZ_CP061071:719756-720133 [Streptococcus mutans B04Sm5]
MLKSYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALEKKLQL

Nucleotide

• Length: 378 bp

>AT172011 NZ_CP079150:c4065954-4065667 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H5AQZ7