Detailed information of TA system TA172009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 163403..164364
• Replicon: chromosome
• Accession: NZ_CP061071
• Organism: Streptococcus mutans B04Sm5

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: A0A2J9QC39
• Locus tag: IBL27_RS00795
• Protein ID: WP_002267097.1
• Coordinates: 163403..163918 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: -
• Locus tag: IBL27_RS00800
• Protein ID: WP_002277323.1
• Coordinates: 163918..164364 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBL27_RS00770	158821..159558	+	738	WP_002283811.1	MerR family transcriptional regulator	-
IBL27_RS00775	159555..160585	-	1031	Protein_131	BtrH N-terminal domain-containing protein	-
IBL27_RS00780	160774..161328	-	555	WP_002264861.1	PadR family transcriptional regulator	-
IBL27_RS00785	161641..162387	+	747	WP_002264862.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
IBL27_RS00790	162411..163271	+	861	WP_002265709.1	DegV family protein	-
IBL27_RS00795	163403..163918	+	516	WP_002267097.1	hypothetical protein	Toxin
IBL27_RS00800	163918..164364	+	447	WP_002277323.1	hypothetical protein	Antitoxin
IBL27_RS00805	164361..164555	+	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
IBL27_RS00810	164948..165394	+	447	WP_002262993.1	50S ribosomal protein L13	-
IBL27_RS00815	165419..165811	+	393	WP_002262992.1	30S ribosomal protein S9	-
IBL27_RS00820	166133..166378	+	246	WP_002264866.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
IBL27_RS00825	166372..166704	+	333	WP_002309274.1	type II toxin-antitoxin system PemK/MazF family toxin	-
IBL27_RS00830	166902..167693	-	792	WP_002288766.1	DUF4037 domain-containing protein	-
IBL27_RS00835	168076..168231	+	156	WP_154079686.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	167860..167988	128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19512.16 Da
• Isoelectric Point: 9.8653

>T172009 WP_002267097.1 NZ_CP061071:163403-163918 [Streptococcus mutans B04Sm5]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Nucleotide

• Length: 516 bp

>T172009 NZ_CP079150:2068104-2068206 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 17010.31 Da
• Isoelectric Point: 9.5767

>AT172009 WP_002277323.1 NZ_CP061071:163918-164364 [Streptococcus mutans B04Sm5]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESIIKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Nucleotide

• Length: 447 bp

>AT172009 NZ_CP079150:c2068213-2068068 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: A0A2J9QC39