Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1924528..1924990 Replicon chromosome
Accession NZ_CP061041
Organism Staphylococcus warneri strain WS479

Toxin (Protein)


Gene name TsaT Uniprot ID A0A2V3ZEQ2
Locus tag IAR39_RS09550 Protein ID WP_002465948.1
Coordinates 1924528..1924713 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A364UQZ8
Locus tag IAR39_RS09555 Protein ID WP_015365250.1
Coordinates 1924733..1924990 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR39_RS09505 1919640..1920005 + 366 WP_058709365.1 hypothetical protein -
IAR39_RS09510 1920326..1920526 + 201 WP_002450876.1 cold-shock protein -
IAR39_RS09515 1920702..1920935 - 234 WP_015365252.1 hypothetical protein -
IAR39_RS09520 1921164..1921403 - 240 WP_002465943.1 hypothetical protein -
IAR39_RS09525 1921868..1922083 - 216 WP_002465949.1 hypothetical protein -
IAR39_RS09530 1922161..1922445 - 285 WP_002465939.1 hypothetical protein -
IAR39_RS09535 1922536..1923288 - 753 WP_187835189.1 poly-gamma-glutamate hydrolase family protein -
IAR39_RS09540 1923553..1923786 + 234 WP_002450870.1 hypothetical protein -
IAR39_RS09545 1923846..1924427 - 582 WP_015365251.1 hypothetical protein -
IAR39_RS09550 1924528..1924713 - 186 WP_002465948.1 hypothetical protein Toxin
IAR39_RS09555 1924733..1924990 - 258 WP_015365250.1 hypothetical protein Antitoxin
IAR39_RS09560 1925284..1925487 + 204 WP_015365249.1 sterile alpha motif-like domain-containing protein -
IAR39_RS09565 1925479..1925712 - 234 WP_002450865.1 hypothetical protein -
IAR39_RS09570 1925921..1926511 + 591 WP_058709949.1 histidine phosphatase family protein -
IAR39_RS09575 1926644..1927138 - 495 WP_002465942.1 GNAT family N-acetyltransferase -
IAR39_RS09580 1927417..1927839 - 423 WP_002450862.1 organic hydroperoxide resistance protein -
IAR39_RS09585 1928015..1928731 + 717 WP_058709950.1 type I 3-dehydroquinate dehydratase -
IAR39_RS09590 1928809..1929348 + 540 WP_002465937.1 nitroreductase -
IAR39_RS09595 1929460..1929783 - 324 WP_015365247.1 thioredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6977.68 Da        Isoelectric Point: 10.1605

>T171967 WP_002465948.1 NZ_CP061041:c1924713-1924528 [Staphylococcus warneri]
MSLHFTILFWLSLIFIVAGAIILAIMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLLFGL

Download         Length: 186 bp

>T171967 NZ_CP079131:c21767-21234 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9908.17 Da        Isoelectric Point: 4.5910

>AT171967 WP_015365250.1 NZ_CP061041:c1924990-1924733 [Staphylococcus warneri]
MKLYIIHAINIILTILFIIFNVIITYNANLDDTLWLVPGLIVCGLIMMISFAIAITKKDLLSEVLFFINIILTLYYIYPI
FYDFL

Download         Length: 258 bp

>AT171967 NZ_CP079131:c22044-21778 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3ZEQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A364UQZ8

References