Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 521016..521526 Replicon chromosome
Accession NZ_CP061041
Organism Staphylococcus warneri strain WS479

Toxin (Protein)


Gene name TsdT Uniprot ID A0A364UNH7
Locus tag IAR39_RS02640 Protein ID WP_002466743.1
Coordinates 521016..521222 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag IAR39_RS02645 Protein ID WP_002466760.1
Coordinates 521233..521526 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR39_RS02620 516605..517966 - 1362 WP_058709706.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IAR39_RS02625 517982..519052 - 1071 WP_002466764.1 D-alanine--D-alanine ligase -
IAR39_RS02630 519410..520600 + 1191 WP_002466775.1 rod shape-determining protein RodA -
IAR39_RS02635 520740..520877 - 138 WP_002466770.1 hypothetical protein -
IAR39_RS02640 521016..521222 - 207 WP_002466743.1 heavy-metal-associated domain-containing protein Toxin
IAR39_RS02645 521233..521526 - 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
IAR39_RS02650 521715..523199 + 1485 WP_058709704.1 cardiolipin synthase -
IAR39_RS02655 523327..523971 + 645 WP_187835313.1 HD domain-containing protein -
IAR39_RS02660 524009..524878 - 870 WP_002466746.1 membrane protein insertase YidC -
IAR39_RS02665 524967..525608 - 642 WP_058709702.1 thiamine phosphate synthase -
IAR39_RS02670 525609..526400 - 792 WP_058709701.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7670.62 Da        Isoelectric Point: 3.8601

>T171965 WP_002466743.1 NZ_CP061041:c521222-521016 [Staphylococcus warneri]
VQQKIVYTAGIETQEQSEAIKNLLTEMIGVYQVDIDINSGNITIEFETPANLNSIEKEIYDAGYKVLY

Download         Length: 207 bp

>T171965 NZ_CP079123:c38662-38246 [Klebsiella pneumoniae subsp. pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT171965 WP_002466760.1 NZ_CP061041:c521526-521233 [Staphylococcus warneri]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT171965 NZ_CP079123:c38889-38659 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNH7

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References