Detailed information of TA system TA171964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 509874..510403
• Replicon: chromosome
• Accession: NZ_CP061041
• Organism: Staphylococcus warneri strain WS479

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: IAR39_RS02580
• Protein ID: WP_058709711.1
• Coordinates: 509874..510236 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A2T4PXF4
• Locus tag: IAR39_RS02585
• Protein ID: WP_002451626.1
• Coordinates: 510233..510403 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR39_RS02560	506904..507674	-	771	WP_002451621.1	RNA polymerase sigma factor SigB	-
IAR39_RS02565	507649..508128	-	480	WP_002466768.1	anti-sigma B factor RsbW	-
IAR39_RS02570	508130..508456	-	327	WP_002466754.1	anti-sigma factor antagonist	-
IAR39_RS02575	508550..509551	-	1002	WP_058709712.1	PP2C family protein-serine/threonine phosphatase	-
IAR39_RS02580	509874..510236	-	363	WP_058709711.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
IAR39_RS02585	510233..510403	-	171	WP_002451626.1	hypothetical protein	Antitoxin
IAR39_RS02590	510495..511643	-	1149	WP_058709710.1	alanine racemase	-
IAR39_RS02595	511695..512069	-	375	WP_058709709.1	holo-ACP synthase	-
IAR39_RS02600	512096..512599	-	504	WP_015364833.1	PH domain-containing protein	-
IAR39_RS02605	512586..514112	-	1527	WP_058709716.1	PH domain-containing protein	-
IAR39_RS02610	514105..514578	-	474	WP_058709708.1	PH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13585.72 Da
• Isoelectric Point: 9.9784

>T171964 WP_058709711.1 NZ_CP061041:c510236-509874 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFHHSKT

Nucleotide

• Length: 363 bp

>T171964 NZ_CP079121:58923-59405 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6300.94 Da
• Isoelectric Point: 3.8309

>AT171964 WP_002451626.1 NZ_CP061041:c510403-510233 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Nucleotide

• Length: 171 bp

>AT171964 NZ_CP079121:58669-58935 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A2T4PXF4