Detailed information of TA system TA171963

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 371630..372436
• Replicon: chromosome
• Accession: NZ_CP061041
• Organism: Staphylococcus warneri strain WS479

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A364UNB4
• Locus tag: IAR39_RS01785
• Protein ID: WP_002466824.1
• Coordinates: 371630..371809 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: IAR39_RS01790
• Protein ID: WP_187835299.1
• Coordinates: 371837..372436 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR39_RS01760	366732..367355	-	624	WP_002466822.1	response regulator transcription factor	-
IAR39_RS01765	367376..368488	-	1113	WP_058710198.1	GAF domain-containing sensor histidine kinase	-
IAR39_RS01770	368666..369496	+	831	WP_002466807.1	RluA family pseudouridine synthase	-
IAR39_RS01775	369555..370940	-	1386	WP_058710199.1	class II fumarate hydratase	-
IAR39_RS01780	371095..371487	-	393	WP_015364871.1	hypothetical protein	-
IAR39_RS01785	371630..371809	-	180	WP_002466824.1	hypothetical protein	Toxin
IAR39_RS01790	371837..372436	-	600	WP_187835299.1	glucosamine-6-phosphate isomerase	Antitoxin
IAR39_RS01795	372616..373086	-	471	WP_002466802.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
IAR39_RS01800	373087..374217	-	1131	WP_058710201.1	tRNA epoxyqueuosine(34) reductase QueG	-
IAR39_RS01805	374459..375181	-	723	WP_002466809.1	amino acid ABC transporter ATP-binding protein	-
IAR39_RS01810	375174..376634	-	1461	WP_002466813.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6901.22 Da
• Isoelectric Point: 3.8441

>T171963 WP_002466824.1 NZ_CP061041:c371809-371630 [Staphylococcus warneri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Nucleotide

• Length: 180 bp

>T171963 NZ_CP079120:5277491-5278024 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22545.52 Da
• Isoelectric Point: 5.1361

>AT171963 WP_187835299.1 NZ_CP061041:c372436-371837 [Staphylococcus warneri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDVSGNLDVSVRKGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT171963 NZ_CP079120:5277214-5277480 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A364UNB4