Detailed information of TA system TA171959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 1952871..1953394
• Replicon: chromosome
• Accession: NZ_CP061040
• Organism: Brucella intermedia strain ZJ499

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IAR37_RS22400
• Protein ID: WP_128006255.1
• Coordinates: 1952871..1953125 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A833FTT8
• Locus tag: IAR37_RS22405
• Protein ID: WP_063620627.1
• Coordinates: 1953152..1953394 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR37_RS22375	1949114..1950232	-	1119	WP_063620631.1	LLM class flavin-dependent oxidoreductase	-
IAR37_RS22380	1950351..1951115	-	765	WP_063620630.1	IclR family transcriptional regulator	-
IAR37_RS22385	1951265..1951538	-	274	Protein_1809	IS3 family transposase	-
IAR37_RS22390	1951822..1952223	-	402	WP_063620629.1	tRNA(fMet)-specific endonuclease VapC	-
IAR37_RS22395	1952223..1952453	-	231	WP_063620628.1	antitoxin	-
IAR37_RS22400	1952871..1953125	-	255	WP_128006255.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAR37_RS22405	1953152..1953394	-	243	WP_063620627.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
IAR37_RS22410	1953773..1954961	+	1189	WP_128006239.1	IS3 family transposase	-
IAR37_RS22415	1955731..1956039	-	309	WP_031346565.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IAR37_RS22420	1956036..1956317	-	282	WP_025091185.1	type II toxin-antitoxin system ParD family antitoxin	-
IAR37_RS22425	1956634..1957440	+	807	WP_063881769.1	DUF4239 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-79)

Antitoxin

• Antitoxin ParD (8-62)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9571.03 Da
• Isoelectric Point: 6.6415

>T171959 WP_128006255.1 NZ_CP061040:c1953125-1952871 [Brucella intermedia]
MFIAIAGQSIATFGPAQAKRYHAELFNALELIAKNLQLAREEISPPARVHPFKAHLVIYHIEEDGTVFVIRLRHAFEDWV
SDPF

Nucleotide

• Length: 255 bp

>T171959 NZ_CP079120:c4259878-4259510 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8927.13 Da
• Isoelectric Point: 8.5908

>AT171959 WP_063620627.1 NZ_CP061040:c1953394-1953152 [Brucella intermedia]
MVTMNVSLPHPMKEWVETQAKTGRYSNASDYVRDLIRKDHMSSDKIAAMQRFVGEGLQSGPGSRSQDELFAVALTQAKNL

Nucleotide

• Length: 243 bp

>AT171959 NZ_CP079120:c4260096-4259875 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A833FTT8