Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1951822..1952453 Replicon chromosome
Accession NZ_CP061040
Organism Brucella intermedia strain ZJ499

Toxin (Protein)


Gene name vapC Uniprot ID A0A833FQA2
Locus tag IAR37_RS22390 Protein ID WP_063620629.1
Coordinates 1951822..1952223 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A833CVC9
Locus tag IAR37_RS22395 Protein ID WP_063620628.1
Coordinates 1952223..1952453 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR37_RS22370 1947719..1949089 - 1371 WP_063620632.1 LLM class flavin-dependent oxidoreductase -
IAR37_RS22375 1949114..1950232 - 1119 WP_063620631.1 LLM class flavin-dependent oxidoreductase -
IAR37_RS22380 1950351..1951115 - 765 WP_063620630.1 IclR family transcriptional regulator -
IAR37_RS22385 1951265..1951538 - 274 Protein_1809 IS3 family transposase -
IAR37_RS22390 1951822..1952223 - 402 WP_063620629.1 tRNA(fMet)-specific endonuclease VapC Toxin
IAR37_RS22395 1952223..1952453 - 231 WP_063620628.1 antitoxin Antitoxin
IAR37_RS22400 1952871..1953125 - 255 WP_128006255.1 type II toxin-antitoxin system RelE/ParE family toxin -
IAR37_RS22405 1953152..1953394 - 243 WP_063620627.1 type II toxin-antitoxin system ParD family antitoxin -
IAR37_RS22410 1953773..1954961 + 1189 WP_128006239.1 IS3 family transposase -
IAR37_RS22415 1955731..1956039 - 309 WP_031346565.1 type II toxin-antitoxin system RelE/ParE family toxin -
IAR37_RS22420 1956036..1956317 - 282 WP_025091185.1 type II toxin-antitoxin system ParD family antitoxin -
IAR37_RS22425 1956634..1957440 + 807 WP_063881769.1 DUF4239 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15087.33 Da        Isoelectric Point: 8.4953

>T171958 WP_063620629.1 NZ_CP061040:c1952223-1951822 [Brucella intermedia]
MLKYMLDTNICIFTIKNRPQQLREAFNRFHDKLCISSVSLMELIYGAEKSAHPEKNLAVVEGFAARLKVLPYDEPAANQT
GQLRAELARSGTPIGPYDQLLAGHARSRGLIMVTNNRREFDRVPGLRVEDWTD

Download         Length: 402 bp

>T171958 NZ_CP079120:c3755823-3755413 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8442.49 Da        Isoelectric Point: 5.0190

>AT171958 WP_063620628.1 NZ_CP061040:c1952453-1952223 [Brucella intermedia]
MEQGAVFQSNRSQAIRLPKAVALPAHVKRVDIVAVGRTRIIAPAGEVWDSWFDGLEATSDFMSERDQPASQEREAF

Download         Length: 231 bp

>AT171958 NZ_CP079120:c3756070-3755804 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A833FQA2

Antitoxin

Source ID Structure
AlphaFold DB A0A833CVC9

References