Detailed information of TA system TA171957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 5138542..5140036
• Replicon: chromosome
• Accession: NZ_CP061038
• Organism: Sphingomonas alpina strain DSM 22537

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: H3Z74_RS24035
• Protein ID: WP_187761964.1
• Coordinates: 5139155..5140036 (+)
• Length: 294 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: H3Z74_RS24030
• Protein ID: WP_187761963.1
• Coordinates: 5138542..5139162 (+)
• Length: 207 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3Z74_RS24015	5134631..5135644	+	1014	WP_187761960.1	PD-(D/E)XK motif protein	-
H3Z74_RS24020	5135637..5137679	+	2043	WP_187761961.1	AIPR family protein	-
H3Z74_RS24025	5137803..5138312	+	510	WP_187761962.1	hypothetical protein	-
H3Z74_RS24030	5138542..5139162	+	621	WP_187761963.1	AbiEi antitoxin N-terminal domain-containing protein	Antitoxin
H3Z74_RS24035	5139155..5140036	+	882	WP_187761964.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H3Z74_RS24040	5141200..5144571	+	3372	WP_187761965.1	DUF4132 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (37-267)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (7-92)

Sequences

Toxin

Protein

• Length: 294 a.a.
• Molecular weight: 32346.89 Da
• Isoelectric Point: 4.6604

>T171957 WP_187761964.1 NZ_CP061038:5139155-5140036 [Sphingomonas alpina]
MAKGTNRAASIKQQLLNLARAEGRVYDVVLVRYALERLLYRISISEMRDRFILKGGMLVTLWIEGGNRETRDVDFLGYGD
SDERKLRDAFAEIMAIDVDDGLVFDIEGLRATAIREEMEYGGVRLRTTAYLERSRIPVTIDIGFGDALAASAPSLAYPSL
LGMEAPQIRTYPPTAVIAEKFQAMVALGVANGRMKDYFDLWAIPRAVELDETALDAAIQATFERRQTDIPVGRPPGLSPA
LTGDETKQRQWRAYAQSIDLESLTLEEVVEAAWALVGPSCARIGARGNSSPES

Nucleotide

• Length: 882 bp

>T171957 NZ_CP079120:c2596168-2596066 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 207 a.a.
• Molecular weight: 22858.17 Da
• Isoelectric Point: 8.4631

>AT171957 WP_187761963.1 NZ_CP061038:5138542-5139162 [Sphingomonas alpina]
MDRLEQTQREQLSAFLDTSPIVRAYELRNAGIAGETIRRAVQSGELVRIARGLYQRADSEVETEQALAEAAKRVPKGVIA
MISALAFHGLTDQMPRRIWVAISARDWAPVPSYPPIRIVELRDKYMQHGIEHHPISGVDVPIFSVSKTLADVFRNSKLVD
RSVAVEGLRAALDQRKATPGEIADAAMAADSWRIMRPYLEALTSNG

Nucleotide

• Length: 621 bp

>AT171957 NZ_CP079120:2596059-2596204 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT