Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 3878197..3878726 Replicon chromosome
Accession NZ_CP061035
Organism Sphingomonas sp. DH-S5

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag H5J25_RS18440 Protein ID WP_202093581.1
Coordinates 3878439..3878726 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag H5J25_RS18435 Protein ID WP_202093580.1
Coordinates 3878197..3878439 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5J25_RS18405 3873262..3874281 + 1020 WP_202093574.1 GGDEF domain-containing protein -
H5J25_RS18410 3874810..3875112 + 303 WP_202093576.1 alkylphosphonate utilization protein -
H5J25_RS18415 3875122..3875830 + 709 Protein_3626 uracil-DNA glycosylase -
H5J25_RS18420 3875827..3876270 + 444 WP_202093577.1 DUF1810 domain-containing protein -
H5J25_RS18425 3876334..3876783 + 450 WP_202093578.1 pyridoxamine 5'-phosphate oxidase family protein -
H5J25_RS18430 3877022..3878071 - 1050 WP_202093579.1 hypothetical protein -
H5J25_RS18435 3878197..3878439 + 243 WP_202093580.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
H5J25_RS18440 3878439..3878726 + 288 WP_202093581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5J25_RS18445 3879013..3880161 + 1149 WP_202093582.1 ATP-binding protein -
H5J25_RS18450 3880158..3880748 + 591 WP_202093584.1 hypothetical protein -
H5J25_RS18455 3880745..3882652 - 1908 WP_202093586.1 phosphomethylpyrimidine synthase ThiC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10973.46 Da        Isoelectric Point: 5.0895

>T171956 WP_202093581.1 NZ_CP061035:3878439-3878726 [Sphingomonas sp. DH-S5]
MRIEVSDEAQDELLGILRYGYDMFGEDASEAYLRGFDNAFALIVVHPAIGTLHDHVRPPIRSLPYGSHRIFYDVFEDFIV
VQRVLHKAMDAERHL

Download         Length: 288 bp

>T171956 NZ_CP079120:1844134-1845456 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9201.21 Da        Isoelectric Point: 4.8411

>AT171956 WP_202093580.1 NZ_CP061035:3878197-3878439 [Sphingomonas sp. DH-S5]
MAQMNISIPDQLKSWAEARVAEGRYSSTSDYVRDLVRRDQEYAEKLQRLQAAIDEGRASPSSERTIEDIIADERQRRAMA

Download         Length: 243 bp

>AT171956 NZ_CP079120:1843868-1844134 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References