Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 591234..591765 Replicon chromosome
Accession NZ_CP061032
Organism Corynebacterium sp. zg-917

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag IAU68_RS02880 Protein ID WP_171194681.1
Coordinates 591472..591765 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag IAU68_RS02875 Protein ID WP_171194680.1
Coordinates 591234..591488 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU68_RS02845 586534..586878 + 345 WP_171194674.1 hypothetical protein -
IAU68_RS02850 586857..587231 + 375 WP_171194675.1 hypothetical protein -
IAU68_RS02855 587305..587544 - 240 WP_171194676.1 toxin -
IAU68_RS02860 587541..587786 - 246 WP_171194677.1 ribbon-helix-helix domain-containing protein -
IAU68_RS02865 588894..589538 - 645 WP_171194678.1 DUF3239 domain-containing protein -
IAU68_RS02870 589550..591190 - 1641 WP_171194679.1 DEAD/DEAH box helicase -
IAU68_RS02875 591234..591488 + 255 WP_171194680.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
IAU68_RS02880 591472..591765 + 294 WP_171194681.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IAU68_RS02885 591762..592958 - 1197 WP_171194682.1 ABC transporter permease -
IAU68_RS02890 592958..593836 - 879 WP_171194683.1 ATP-binding cassette domain-containing protein -
IAU68_RS02895 593833..594330 - 498 WP_171194684.1 hypothetical protein -
IAU68_RS02900 594327..594584 - 258 WP_171194685.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 568489..602652 34163


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Antitoxin ParD

(3-80)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11325.94 Da        Isoelectric Point: 9.7183

>T171945 WP_171194681.1 NZ_CP061032:591472-591765 [Corynebacterium sp. zg-917]
MKYRLRRQAESDLVEIWNYTAVRWGMSQAERYVGQVLYMLDMLGGNPRLGSSASEVRSGYRKKAVGSHIIFYREDDGVID
VVRILHQRMDLQHHLNS

Download         Length: 294 bp

>T171945 NZ_CP079115:c2774968-2773646 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9511.66 Da        Isoelectric Point: 4.5925

>AT171945 WP_171194680.1 NZ_CP061032:591234-591488 [Corynebacterium sp. zg-917]
MAAKNTSVVLGERYDKFIAELLEDGRYASASEVLREGLRLVEEREQKFKALNDALEKGELSEVVHDFDPDAFIARMKNNH
EVSA

Download         Length: 255 bp

>AT171945 NZ_CP079115:c2775234-2774968 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCACTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References